Vonoprazan-Fumarate-TAK-438-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEVonoprazan FumarateCat. No.: HY-15295CAS No.: 1260141-27-2Synonyms: TAK-438分式: CHFNOS分量: 461.46作靶点: Proton Pump作通路: Membrane Transporter/Ion Channel储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验

2、DMSO : 50 mg/mL (108.35 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1670 mL 10.8352 mL 21.6704 mL5 mM 0.4334 mL 2.1670 mL 4.3341 mL10 mM 0.2167 mL 1.0835 mL 2.1670 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，

3、体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.42 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.42 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil

4、1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (5.42 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Vonoprazan Fumarate (TAK-438)有种服活性的 钾竞争性酸阻断剂，抑制 H+, K+-ATPase的 IC50 值为19 nM。户使本产品发表的科研献 Br J Clin Pharmacol. 2019 Mar 7. Drug Metab Dispos. 2016 Oct;44(10):1543-9.See more customer

5、validations on HYPERLINK / www.MedChemEREFERENCES1. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.2. Hor

6、i Y, et al. 1-5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl-N-methylmethanamine monofumarate (TAK-438), a novel andpotent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.3. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole inanimals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only