Ro-25-6981 - iGluR 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERo 25-6981Cat. No.: HY-13993CAS No.: 169274-78-6分式: CHNO分量: 339.47作靶点: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO : 100 m

2、g/mL (294.58 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9458 mL 14.7288 mL 29.4577 mL5 mM 0.5892 mL 2.9458 mL 5.8915 mL10 mM 0.2946 mL 1.4729 mL 2.9458 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议

3、您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.36 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.36 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility

4、: 2.5 mg/mL (7.36 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂，对于重 组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 M。REFERENCES1. Fischer G, et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate recep

5、tors containing the NR2B subunit.Characterization in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.2. Lynch DR, et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol.2001 Mar 30;416(3):185-95.3. Jiang M, et al. Antinociception

6、and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonistof the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820