Exemestane-FCE-24304-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEExemestaneCat. No.: HY-13632CAS No.: 107868-30-4Synonyms: FCE 24304; EXE分式: CHO分量: 296.4作靶点: Aromatase作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 54 mg/mL (182.19 mM)* means

2、soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3738 mL 16.8691 mL 33.7382 mL5 mM 0.6748 mL 3.3738 mL 6.7476 mL10 mM 0.3374 mL 1.6869 mL 3.3738 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现

3、现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.43 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.43 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChe

4、mE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.43 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Exemestane(FCE 24304)芳酶（aromatase）抑制剂，能抑制胎盘和 巢芳酶，IC50分别为30 nM和40 nM。REFERENCES1. Di Salle, E., et al., Novel aromatase and 5 alpha-reductase inhibitors. J Steroid Biochem Mol Biol, 1994. 49(4-6

5、): p. 289-94.2. Miki, Y., et al., Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protectiveeffects induced by exemestane. Bone, 2007. 40(4): p. 876-87.3. Wang, X. and S. Chen, Aromatase destabilizer: novel action of exemestane, a food and dr

6、ug administration-approved aromataseinhibitor. Cancer Res, 2006. 66(21): p. 10281-6.4. Goss, P.E., et al., Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on boneand lipid metabolism in ovariectomized rats. Clin Cancer Res, 2004. 10(17): p.

7、5717-23.5. Zaccheo, T., D. Giudici, and E. Di Salle, Inhibitory effect of combined treatment with the aromatase inhibitor exemestane and tamoxifenon DMBA-induced mammary tumors in rats. J Steroid Biochem Mol Biol, 1993. 44(4-6): p. 677-80.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use