Demecarium-Bromide-BC-48-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDemecarium BromideCat. No.: HY-B1626ACAS No.: 56-94-0Synonyms: BC-48分式: CHBrNO分量: 716.59作靶点: AChE作通路: Neuronal Signaling储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO :

2、160 mg/mL (223.28 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.3955 mL 6.9775 mL 13.9550 mL5 mM 0.2791 mL 1.3955 mL 2.7910 mL10 mM 0.1395 mL 0.6977 mL 1.3955 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作

3、液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.67 mg/mL (3.73 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.67 mg/mL (3.73 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolu

4、bility: 2.67 mg/mL (3.73 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Demecarium Bromide (BC-48)种有效的 cholinesterase 抑制剂，Kiapp 值为 0.15 M 1。DemecariumBromide (BC-48) 作青光眼治疗剂 2。IC50 & Target Kiapp: 0.15 M (Cholinesterase) 1体内研究 Demecarium Bromide (0.125 and

5、 0.5%) causes long-term miosis and decreases intraocular pressure (IOP)in beagles with both normotensive eyes and inherited glaucoma 1.REFERENCES1. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. JPharmacol Exp Ther.

6、 1982 Oct;223(1):20-4.2. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size inbeagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-