Avasimibe-CI-1011-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAvasimibeCat. No.: HY-13215CAS No.: 166518-60-1Synonyms: CI-1011; PD-148515分式: CHNOS分量: 501.72作靶点: Acyltransferase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO

2、 : 28 mg/mL (55.81 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.25 mg/mL (4.48 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.25 mg/mL (4.48 mM); Suspended solution; Need ultrasonic3. 请依序添加每种溶剂： 10% DMSO 9

3、0% corn oilSolubility: 2.25 mg/mL (4.48 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Avasimibe种可服的酰基辅酶A: 胆固醇酰基转移酶 (ACAT) 抑制剂，IC50 分别为24 和 9.2 M。户使本产品发表的科研献 Oncol Lett. 2019 Jun.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Tardif JC et al. Effects of the acyl coenzyme A:choleste

4、rol acyltransferase inhibitor avasimibe on human atherosclerotic lesions.Circulation, 2004 Nov 23, 110(21):3372-7.2. Raal FJ et al. Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilialhypercholesterolemia. Atherosclerosis, 2003 Dec, 171

5、(2):273-9.3. Delsing DJ et al. Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-loweringeffect in ApoE*3-Leiden mice. Circulation, 2001 Apr 3, 103(13):1778-86.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589