2课程格式要求化工2006年模版3摘要

1、分 子 印 迹 分 离 技 术(居中 3 号黑体加深)（空一行）摘 要(居中小 3 号黑体加深)（空一行）（4 号宋体，单倍间距，首行缩进 2 字）分子印迹（Molecular Impring）是一种新的、很有发展潜力的分离技术。利用分子印迹技术，能够具有特异识别功能的色谱介质。它是将功能单体，在模板分子(目标分子，又称印迹分子)的存在下，交联聚合，然后洗脱除去模板分子，这样制得的聚合物，在空穴和功能基排布上与目标分子具有互补的结构，因此在分子识别中有着特殊的选择性和良好的前景。本文利用分子印迹技术对药物性拆分、天然产物葛根素及蛋白质的印迹进行了研究，建立了分子印迹亲和模型，对分子印迹进行了定

2、量描述。主要工作如下：1、在模板分子(S)-萘普生的存在下，采用丙烯酰胺为功能单体，以二甲基丙烯酸乙二醇酯为交联剂，出(S)-萘普生的分子印迹聚合物(MIPs)；优化了模板分子、功能单体、交联剂和致孔剂等对MIPs的影响；5、利用成球备出粒径均匀的壳聚糖球形介质。了多种对成球的影响，优化了成球条件。采用滴加成球备出球形壳聚糖介质，研究了三聚磷酸钠溶液浓度及空气流速对成球的影响，得到其最佳条件为：三聚磷酸钠溶液浓度 3%； 空气流量为1.8m3min1，线速度为 23.81mh1。采用滴加成球法，以壳聚糖为功能单体，对蛋白质血红蛋白的分子印迹进行了初探。研究了温度、壳聚糖浓度和血红蛋白浓度对分子

3、印迹效果的影响，结果表明在下列条件下印迹效果较好：壳聚糖浓度为 4%，交联温度 40，血红蛋白浓度 3mgmL1。（空一行）（4 号黑体加深）：分子印迹，手性拆分，亲和吸附模型，热力学，葛根素，血红蛋白MOLECULAR IMPRING SEPARATIONTECHNIQUE （3 号加深）（空 3 行）ABSTRACT（3 号加深）（空 2 行）采用 4 号字体Molecular impring is a new and potential separation technique forpreparing spelized recognition chromatography media.

4、 The pros ofthe preparation consists of ：(1) mixing the template molecules withmonomers with appropriate functional groups, (2) low temperature andphoto polymerization, and (3) extracting the template molecules from thepolymer,whichleavescavitiesinsidethepolymerstarecomplementaryerms of size, sh, an

5、d functional group orienionto those of the template molecules. The technique has been appdwidely in enantioselective separation for a variety of molecules, such asamino acids and their derivatives, free sugars, and racemic drugs.histhesis, chiral separation of drugs and preparation of pueraria using

6、molecular impring and impring of protein were studied. Molecularimpring affinity mwas established, and utilized to descriptficationally impred separation.his study, preparation of chitosan molecular impred resins werestudied, and a simple method with a nozzle was developed, in whichmolecularly impred chitosan resin was made for hemoglobin as “pr”molecule and chlorohydrin was used as crosslinker. The conditions forpreparation spherical resin were optimized. Results showedt chitosanresin prepared had spelized selective to hemo