WAY-100635-Maleate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEWAY-100635 MaleateCat. No.: HY-10349ACAS No.: 1092679-51-0分式: CHNO分量: 538.64作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 250 mg/m

2、L (464.13 mM)H2O : 25 mg/mL (46.41 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8565 mL 9.2826 mL 18.5653 mL5 mM 0.3713 mL 1.8565 mL 3.7131 mL10 mM 0.1857 mL 0.9283 mL 1.8565 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL

3、ACTIVITY物活性 WAY-100635 Maleate有效的，5-HT1A 的选择性抑制剂，其 pIC50值为 8.87，pA2 值为 9.71。IC50 & Target 5-HT1A Receptor 5-HT1A Receptor8.87 (pIC50) 9.71 (pA2)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE体外研究 WAY-100635 Maleate is a potent and, at high concentrations, an insurmountable antagonist of the 5-HT1A

4、receptor agonist action of 5-carboxamidotryptamine, with an apparent pA2 value (at 0.3 nM) of 9.71. WAY-100635 displaces specific binding of the 5-HT1A radioligand, 3H8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a plCIC50 of 8.87 1.REFERENCES1. Forster EA, et al. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur J Pharmacol. 1995 Jul25;281(1):81-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>