Damascenone-E-Z-Damascenone-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEDamascenoneCat.No.:HY-N2543CASNo.:23696-85-7Synonyms:(E/Z)-Damascenone分⼦式:C₁₃H₁₈O分⼦量:190.28作⽤靶点:NF-κB作⽤通路:NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性数据体外实验DMSO:100mg/mL(525.54mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM5.2554mL26.2771mL52.5541mL5mM1.0511mL5.2554mL10.5108mL10mM0.5255mL2.6277mL5.2554mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(13.14mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(13.14mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(13.14mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Damascenone((E/Z)-Damascenone)于Epipremnumpinnatum的具有抗炎活性的活性化合物。DamascenoneE-和Z-异构体⼤马⼠⾰酮的混合物。体外研究β-DamascenonealsoinhibitstheupregulationofinflammatoryproteinsasdemonstratedbyimmuneassaysforcellsurfaceE-selectinandsecretedTNF-α[1].β-DamascenoneinhibitsNF-κBsignalingpathwayinvitroinhumancellularsystemsthathasbeenactivatedwithdifferentinflammatorystimuli[1].REFERENCES[1].San-PoPan,etal.C13MegastigmaneDerivativesFromEpipremnumpinnatum:β-DamascenoneInhibitstheExpressionofPro-InflammatoryCytokinesandLeukocyteAdhesionMoleculesasWellasNF-κBSignalingMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;