Fmoc-3VVD-OH-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEFmoc-3VVD-OHCat.No.:HY-78921CASNo.:863971-44-2分⼦式:C₃₆H₅₁N₃O₇分⼦量:637.81作⽤靶点:ADCLinker作⽤通路:Antibody-drugConjugate/ADCRelated储存⽅式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性数据体外实验DMSO:≥37mg/mL(58.01mM)H2O:<0.1mg/mL(insoluble)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM1.5679mL7.8393mL15.6787mL5mM0.3136mL1.5679mL3.1357mL10mM0.1568mL0.7839mL1.5679mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5mg/mL(7.84mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性Fmoc-3VVD-OH⼀种可降解(non-cleavable)的ADC连接桥，⽤于抗体药物结合物(ADCs)的合成。IC50&TargetCleavable体外研究ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.REFERENCES[1].MichinoriAkaiwa,etal.SynthesisandEvaluationofLinearandMacrocyclicDolastatin10AnaloguesContainingPyrrolidineRingModifications.ACSOmega.2018May31;3(5):5212-5221.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: