Heparin-sodium-salt-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEHeparinsodiumsaltCat.No.:HY-17567ACASNo.:9041-08-1分⼦式:(C₁₄H₂₅NO₂₀S₃)n.xNa作⽤靶点:Autophagy作⽤通路:Autophagy储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)溶解性数据体H2O:≥150mg/mL外*"≥"meanssoluble,butsaturationunknown.实请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制验储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性Heparinsodiumsalt(Sodiumheparin)⼀种抗凝剂，可与抗凝⾎酶III(ATIII)可逆地结合，⼤⼤加快了ATIII使凝⾎酶因⼦IIa和Xa失活的速度。Heparinsodiumsalt显著抑制外泌体-细胞相互作⽤。IC50&TargetAntithrombinIII[1]体外研究Heparinisapotentanticoagulantdrugbasedonitsabilitytoacceleratetherateatwhichantithrombininhibitsserineproteasesinthebloodcoagulationcascade.Heparinandthestructurallyrelatedheparansulfatearecomplexlinearpolymerscomprisedofamixtureofchainsofdifferentlength,havingvariablesequences.Heparininteractesmosttightlywithpeptidescontainingacomplementarybindingsiteofhighpositivechargedensity.HeparinandheparansulfatepredominantlyexhibitlinearhelicalsecondarystructureswithsulfoandcarboxylgroupsdisplayedatdefinedintervalsandindefinedorientationsalongthepolysaccharidebackboneHeparinresemblesDNAasbotharehighlychargedlinearpolymersthatbehaveaspolyelectrolytes.HeparinbelievedtofunctionasananticoagulantprimarilythroughitsinteractionwithATIIIbyenhancingAT-III-mediatedinhibitionofbloodcoagulationfactors,includingthrombinandfactorXa.HeparinbindstoATIIIandthrombininaternarycomplex,increasingthebimolecularrateconstantfortheinhibitionofthrombinbyafactof2000.Heparinisprincipallylocatedinthegranulesoftissuemastcellsthatarecloselyassociatedwiththeimmuneresponse.HeparinmakesnumerouscontactswithbothFGF-2andFGFR-1stabilizingFGF–FGFR1/2www.MedChemEwww.MedChemEbinding.HeparinalsomakescontactswiththeFGFR-1oftheadjacentFGF–FGFRcomplex,thusseemingtopromoteFGFRdimerization[1].户使⽤本产品发表的科研⽂献•Immunity.2021Apr7;S1074-7613(21)00123-0.•Biomaterials.2021Jan;268:120585.•Biomaterials.2018Aug;175:93-109.•CancerRes.2019Sep15;79(18):4729-4743.•ACSApplMaterInterfaces.2018Aug8;10(31):26128-26141.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].CapilaI,etal.Heparin-proteininteractions.AngewChemIntEdEngl.2002Feb1;41(3):391-412.[2].AnuragPurushothaman,etal.FibronectinontheSurfaceofMyelomaCell-derivedExosomesMediatesExosome-CellInteractions.JBiolChem.2016Jan22;291(4):1652-63.McePdfHeight关注MCE中国公众号，

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