3-Deoxyuridine-5-triphosphate-trisodium-3-dUTP-trisodium-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE3'-Deoxyuridine-5'-triphosphatetrisodiumCat.No.:HY-135780ASynonyms:3'-dUTPtrisodium分⼦式:C₉H₁₅N₂Na₃O₁₄P₃分⼦量:537.11作⽤靶点:NucleosideAntimetabolite/Analog;DNA/RNASynthesis;EndogenousMetabolite作⽤通路:CellCycle/DNADamage;MetabolicEnzyme/Protease储存⽅式:-20°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性数据体外实验H2O:20mg/mL(37.24mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.8618mL9.3091mL18.6182mL5mM0.3724mL1.8618mL3.7236mL10mM0.1862mL0.9309mL1.8618mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性3'-Deoxyuridine-5'-triphosphatetrisodium(3'-dUTPtrisodium)⼀种核苷酸类似物，可抑制DNA依赖性RNA聚合酶I和II(RNApolymerasesI和II)，强烈并竞争性地抑制UTP掺⼊到RNA中，Ki值为2.0μM。体外研究3'-Deoxyuridine-5'-triphosphate(3'-dUTP)issynthesizedstartingfromcordycepiningoodyield.3'-Deoxyuridine-5'-triphosphatestronglyandcompetitivelyinhibitstheincorporationsofUTPintoRNAbytheRNApolymerases.3'-Deoxyuridine-5'-triphosphatewillbeusefulinstudiesatthemolecularlevelonthe1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemErelationshipoftemplateandsubstrateinRNAsynthesiswithchromatin,isolatednucleiorpermeablecells,becauseitdoesnothaveanyeffectonpoly(rA)synthesis[1].REFERENCES[1].MSaneyoshi,etal.InhibitoryEffectsof3'deoxycytidine5'-triphosphateand3'-deoxyuridine5'-triphosphateonDNA-dependentRNAPolymerasesIandIIPurifiedFromDictyosteliumDiscoideumCells.NucleicAcidsRes.1981Jul10;9(13):3129-38.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-