AKR1C3-IN-4-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAKR1C3-IN-4Cat.No.:HY-138557CASNo.:1284180-11-5分⼦式:C₁₄H₁₀F₃NO₂分⼦量:281.23作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:100mg/mL(355.58mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.5558mL17.7790mL35.5581mL5mM0.7112mL3.5558mL7.1116mL10mM0.3556mL1.7779mL3.5558mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(8.89mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(8.89mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(8.89mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性AKR1C3-IN-4⼀种有效的，选择性醛酮还原酶1C3(AKR1C3)抑制剂，IC50为0.56μM。AKR1C3-IN-4具有⽤于去势抵抗性前列腺癌(CRPC)研究的潜⼒。IC50&TargetIC50:0.56μM(AKR1C3)and15.1μM(AKR1C2)[1]体外研究AKR1C3-IN-4hasanIC50of15.1μMforAKR1C2[1].REFERENCES[1].AdegokeOAdeniji,etal.Developmentofpotentandselectiveinhibitorsofaldo-ketoreductase1C3(type517β-hydroxysteroiddehydrogenase)basedonN-phenyl-aminobenzoatesandtheirstructure-activityrelationships.JMedChem.2012Mar8;55(5):2311-23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02