Rac-X77-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(Rac)-X77Cat.No.:HY-136298CASNo.:2144491-78-9分⼦式:C₂₇H₃₃N₅O₂分⼦量:459.58作⽤靶点:SARS-CoV作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(543.97mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1759mL10.8795mL21.7590mL5mM0.4352mL2.1759mL4.3518mL10mM0.2176mL1.0879mL2.1759mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.53mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(4.53mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.53mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性(Rac)-X77X77的外消旋体。X77SARS-CoV-2蛋⽩酶(SARS-CoV-2Mpro)的有效⾮共价键抑制剂。X77与SARS-CoV-2Mpro结合的Kd值为0.057μM。IC50&TargetKd:0.057μM(SARS-CoV-2Mpro)[2]体外研究X77canbindtoSARS-CoV-2Mpro(PDBcode:6W63).SARS-CoV-2Mpro(PDBcode:6W63)isthemainproteaseofSARS-CoV-2andisoneofthemostimportantdrugtargetsamongcoronaviruses[1].REFERENCES[1].SohiniChakraborti,etal.DrugRepurposingApproachTargetedAgainstMainProteaseofSARS-CoV-2Exploiting‘NeighbourhoodBehaviour’in3DProteinStructuralSpaceand2DChemicalSpaceofSmallMolecules.[2].AlexanderMAndrianov,etal.Computationaldiscoveryofsmalldrug-likecompoundsaspotentialinhibitorsofSARS-CoV-2mainprotease.JBiomolStructDynMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8