T-91825-PPI-0903M-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemET-91825Cat.No.:HY-105049CASNo.:189345-04-8Synonyms:PPI-0903M分⼦式:C₂₂H₂₀N₈O₅S₄分⼦量:604.7作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(165.37mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6537mL8.2686mL16.5371mL5mM0.3307mL1.6537mL3.3074mL10mM0.1654mL0.8269mL1.6537mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(4.13mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(4.13mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性T-91825(PPI-0903M)⼀种N-膦酰型头孢素，TAK-599的活性形式。T-91825对⾰兰⽒阳性和⾰兰⽒性均有活性。体外研究PPI-0903MisveryactiveagainstS.aureus(MIC50=0.25μg/mL),includingmethicillin-resistant(MRSA)strains(MIC50=1μg/mL)[1].PPI-0903Misactiveagainsthetero-vancomycin-intermediateS.aureus(100strains),withMIC50srangingfrom0.25to4μg/mL[1].体内研究AK-599(20mg/kg;s.c.threetimesadayfor2days)decreasesthebacterialcellcountsinlungsmorethan99.9%inamousepneumoniamodelcausedbyMRSA[2].REFERENCES[1].SaderHS,et,al.AntimicrobialactivityandspectrumofPPI-0903M(T-91825),anovelcephalosporin,testedagainstaworldwidecollectionofclinicalstrains.AntimicrobAgentsChemother.2005Aug;49(8):3501-12.[2].IizawaY,et,al.InvitroantimicrobialactivityofT-91825,anovelanti-MRSAcephalosporin,andinvivoanti-MRSAactivityofitsprodrug,TAK-599.JInfectChemother.2004Jun;10(3):146-56.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: