Thalidomide-NH-PEG2-COOH-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEThalidomide-NH-PEG2-COOHCat.No.:HY-138772CASNo.:2412056-45-0分⼦式:C₂₀H₂₃N₃O₈分⼦量:433.41作⽤靶点:E3LigaseLigand-LinkerConjugates作⽤通路:PROTAC储存⽅式:-20°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性数据体外实验DMSO:125mg/mL(288.41mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3073mL11.5364mL23.0728mL5mM0.4615mL2.3073mL4.6146mL10mM0.2307mL1.1536mL2.3073mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Thalidomide-NH-PEG2-COOH⼀种合成的E3连接酶配体-linker偶联物，包含于Thalidomide的cereblon配体和1个linker[1]。IC50&TargetCereblon体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEselectivelydegradetargetproteins[2].REFERENCES[1].SatoT,etal.Cereblon-BasedSmall-MoleculeCompoundstoControlNeuralStemCellProliferationinRegenerativeMedicine.FrontCellDevBiol.2021;9:629326.Published2021Mar11.[2].NalawanshaDA,etal.PROTACs:AnEmergingTherapeuticModalityinPrecisionMedicine.CellChemBiol.2020;27(8):998-1003.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559