Dopamine-ASL279-free-base-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDopamineCat.No.:HY-B0451CASNo.:51-61-6Synonyms:ASL279freebase分⼦式:C₈H₁₁NO₂分⼦量:153.18作⽤靶点:DopamineReceptor;EndogenousMetabolite;Ferroptosis作⽤通路:GPCR/GProtein;NeuronalSignaling;MetabolicEnzyme/Protease;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Dopamine在脑⿊质，脑腹侧被盖区和下丘脑中产⽣的⼀种⼉茶酚胺类神经递质，在⼤脑和⾝体中起重要作⽤[1]。Dopamine通过D2多巴胺受体(D2dopaminereceptor)来诱导VEGFR2的内吞作⽤，这对于促进⾎管⽣成⾄关重的[2]。IC50&TargetHumanEndogenousMetaboliteMicrobialMetaboliteD2DopamineReceptor体外研究Vascularpermeabilityfactor/vascularendothelialgrowthfactor(VPF/VEGF)stronglystimulateshumanumbilicalveinendothelialcells(HUVECs)proliferation.ThestimulatoryeffectofVPF/VEGFisabrogatedbyDopamine(1µM;24hours)[2].CellProliferationAssay[2]CellLine:HUVECsConcentration:1µMIncubationTime:24hoursResult:InhibitedVPF/VEGF-inducedHUVECproliferationspecificallythroughitsD2receptor.体内研究Dopamine(50mg/kg;i.p.injection;days1-7)stronglyandselectivelyinhibitsthevascularpermeabilizingandangiogenicactivitiesofVPF/VEGF[2].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAnimalModel:SyngeneicC3Heb/FeJmicewithMOTascitestumors[2]Dosage:50mg/kgAdministration:I.p.injection;7daysResult:Correspondingto~5%ofthemedianlethaldose(LD50)inmice)beginningat24hoursaftertumor-cellinjectionandcontinuingdailyfor7days.户使⽤本产品发表的科研⽂献•BiomedPharmacother.2019Nov;119:109419.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].JuárezOlguínH,etal.TheRoleofDopamineandItsDysfunctionasaConsequenceofOxidativeStress.OxidMedCellLongev.2016;2016:9730467.[2].BasuS,etal.Theneurotransmitterdopamineinhibitsangiogenesisinducedbyvascularpermeabilityfactor/vascularendothelialgrowthfactor.NatMed.2001May;7(5):569-74.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4