Bupropion-morpholinol-Hydroxy-Bupropion-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBupropionmorpholinolCat.No.:HY-12766CASNo.:357399-43-0Synonyms:HydroxyBupropion分⼦式:C₁₃H₁₈ClNO₂分⼦量:255.74作⽤靶点:DopamineTransporter;nAChR作⽤通路:NeuronalSignaling;MembraneTransporter/IonChannel储存⽅式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:20mg/mL(78.20mM;Needultrasonicandwarming)Ethanol:20mg/mL(78.20mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.9102mL19.5511mL39.1022mL5mM0.7820mL3.9102mL7.8204mL10mM0.3910mL1.9551mL3.9102mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Bupropionmorpholinol(HydroxyBupropion)Bupropion的主代谢物。Bupropionmorpholinol在体外抑制多巴胺、去甲肾上腺素转运蛋⽩和α4β2烟碱受体。Bupropionmorpholinol有助于抗抑郁和戒烟活动。1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIC50&TargetDopaminetransporter[2],Norepinephrinetransporter[2],α4β2nicotinicreceptor[2]体外研究BupropionmorpholinolisproducedfromBupropionbythegeneticallypolymorphicenzymeCYP2B6invivo[1].Bupropionmorpholinolinhibits[3H]norepinephrineuptakewithanIC50of1.7μM[2].REFERENCES[1].ZhuAZX,et,al.CYP2B6andbupropion'ssmoking-cessationpharmacology:theroleofhydroxybupropion.ClinPharmacolTher.2012Dec;92(6):771-7.[2].DamajMI,et,al.Enantioselectiveeffectsofhydroxymetabolitesofbupropiononbehaviorandonfunctionofmonoaminetransportersandnicotinicreceptors.MolPharmacol.2004Sep;66(3):675-82.[3].DamajMI,et,al.Effectsofhydroxymetabolitesofbupropiononnicotinedependencebehaviorinmice.JPharmacolExpTher.2010Sep1;334(3):1087-95.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82