VUT-MK142-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVUT-MK142Cat.No.:HY-122610CASNo.:1313491-22-3分⼦式:C₁₇H₂₂N₄O分⼦量:298.38作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:25mg/mL(83.79mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.3514mL16.7572mL33.5143mL5mM0.6703mL3.3514mL6.7029mL10mM0.3351mL1.6757mL3.3514mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.5mg/mL(8.38mM);Suspendedsolution;Needultrasonic2.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(8.38mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性VUT-MK142⼀种强效⼼肌合成剂，可促进⼼脏前中胚层向⼼肌细胞分化，有助于⼲细胞向⼼肌细胞分化进⾏的⼼脏修复。体外研究VUT-MK142possessespromisingcardiomyogeniceffectsonvariouscelltypes.VUT-MK142showsaremarkableeffectonbothP19andC2C12cells.ComparedtoCgC,VUT-MK142-treatmentleadstoamarkedlystrongerup-regulationoftheexpressionofANF[1].VUT-MK142(1μM,7daytreatment)significantly(p<0.05)increasestheluciferasesignalby3.1±0.3luciferase(n=5)-foldinP19cells[1].REFERENCES[1].MoumitaKoley,etal.VUT-MK142:anewcardiomyogenicsmallmoleculepromotingthedifferentiationofpre-cardiacmesodermintocardiomyocytes.Medchemcomm.2013Aug1;4(8):1189-1195.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;