FABPs-ligand-6-MF6-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFABPsligand6Cat.No.:HY-145990Synonyms:MF6分⼦式:C₂₈H₂₇FN₂O₃分⼦量:458.52作⽤靶点:FABP作⽤通路:MetabolicEnzyme/Protease储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:250mg/mL(545.23mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1809mL10.9046mL21.8093mL5mM0.4362mL2.1809mL4.3619mL10mM0.2181mL1.0905mL2.1809mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.54mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性FABPsligand6(MF6)⼀种FABP5和FABP7抑制剂，KD值分别为874nM和20nM。FABPsligand6可⽤于多发性硬化症的研究。IC50&TargetKD:20nM(FABP7),874nM(FABP5)[1]体外研究FABPsligand6(MF6)rescuesmitochondrialfunctionbyblockingvoltagedependentanionchannel(VDAC)-1-dependentmitochondrialmacroporeformationinducedbypsychosineinKG-1Ccells,aFABP5-mediatedinjury[1].体内研究MF6(1mg/kg;i.g.;dailyfor4weeks)improvestheseverityofEAE(experimentalautoimmuneencephalomyelitis)andattenuatesoxidativelevelsandtheinflammatoryresponse[1].AnimalModel:8-10-week-oldfemaleC57BMF/6JmicewithMOG35-55-administeredexperimentalautoimmuneencephalomyelitis(EAE)mousemodel[1]Dosage:1mg/kgAdministration:Intragastricadministration,dailyfor4weeksResult:AttenuatedEAEsymptoms,decreasedoxidativestress,inhibitedastrocyteactivationandprotectedoligodendrocytes.REFERENCES[1].ChengA,etal.Anovelfattyacid-bindingprotein5and7inhibitoramelioratesoligodendrocyteinjuryinmultiplesclerosismousemodels.EBioMedicine.2021Oct;72:103582.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.T