Rac-CFT7455-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(Rac)-CFT7455Cat.No.:HY-144841ACASNo.:2504233-68-3分⼦式:C₂₈H₂₇N₃O₄分⼦量:469.53作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:62.5mg/mL(133.11mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1298mL10.6489mL21.2979mL5mM0.4260mL2.1298mL4.2596mL10mM0.2130mL1.0649mL2.1298mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(4.43mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性(Rac)-CFT7455⼀种Ikaros/Aiolos降解剂，通过泛素蛋⽩酶体途径起作⽤，对NCIH929.1细胞的GI50为0.05nM。(Rac)-CFT7455具有抗癌活性的CFT7455的外消旋异构体。IC50&TargetIkaros,Aiolos[1]REFERENCES[1].DavidProiaetal.Advantageoustherapiesfordisordersmediatedbyikarosoraiolos.WO2022032132A1(compound5)[2].JamesA.Henderson,etal.AbstractLB007:CFT7455:Anovel,IKZF1/3degraderthatdemonstratespotenttumorregressioninIMiD-resistantmultiplemyeloma(MM)xenograftmodels.CancerRes(2021)81(13_Supplement):LB007.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>