Antitumor-agent-75-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAntitumoragent-75Cat.No.:HY-151295分⼦式:C₂₆H₂₃FN₆分⼦量:438.5作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Antitumoragent-75⼀种新型有效的抗肿瘤剂。Antitumoragent-75对癌症和正常⼈类细胞系具有细胞毒性作⽤。Antitumoragent-75与Antitumoragent-74(HY-151292)结合使⽤时对⼈肺腺癌（细胞系A549）具有⾼度选择性的细胞毒作⽤，其IC50值为2.8μM。Antitumoragent-75可⽤于癌症的研究。IC50&TargetIC50:2.8μM(A549cells)[1]体外研究Antitumoragent-75(14da)showsahighlyselectivecytotoxiceffect(combinedwith13da,mrBIQ13da/14da)againsthumanlungadenocarcinoma(celllineA549)withanIC50valueof2.8μM[1].Antitumoragent-75(1,5,25,50,100μM;0-48h)(mriBIQ13da/14da)hasthecytotoxiceffectinA549cells[1].Antitumoragent-75(1,2.5,and5μM;12h)(mriBIQ13da/14da)hasthemechanismofthecytotoxiceffectonA549cellsmaybeassociatedwiththestoppingofthecellcycleinphaseSandinhibitionofDNAsynthesisaswellaswiththeinductionofmithochondrialapoptosis[1].Antitumoragent-75(1,2.5and5μM)increasestheproductionofreactiveoxygenspecies(ROS)andinducesmitochondrialapoptosisinA549cells.CellCytotoxicityAssay[1]CellLine:sevencancercelllinesandWI38(theNormalHumanFetalLungFibroblastline)Concentration:1-100μMIncubationTime:Result:Exhibitedgreateractivityagainstmostofthecancerlinesandnormalhumancelllines.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECellProliferationAssay[1]CellLine:A549CellConcentration:1,5,25,50,100μMIncubationTime:0-48hResult:LeadtoasharpdecreasethepresenceofmriBIQ13da/14daatconcentrationsclosetotheIC50valuesintherateofcelldivision.CellCycleAnalysis[1]CellLine:A549cellsConcentration:1,2.5,and5μMIncubationTime:12hResult:IncreasedthenumberofcellsintheS-phasewithmnBIQ13da/14daatconcentrationsof1,2.5,and5μMat49.0%,66.3%,and68.0%,respectively.ApoptosisAnalysis[1]CellLine:A549cellsConcentration:1,2.5and5μMIncubationTime:Result:(mrBIQ13da/14da)InducedmitochondrialapoptosisinA549cells.REFERENCES[1].VakhidA.Mamedov,etal.SynthesisofMorpholine‑,Piperidine‑,andN‑SubstitutedPiperazine-Coupled2‑(Benzimidazol-2-yl)-3-arylquinoxalinesasMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea