Cidofovir-diphosphate-tri-triethylamine-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECidofovirdiphosphatetri(triethylamine)Cat.No.:HY-131606B分⼦式:C₂₆H₆₁N₆O₁₂P₃分⼦量:742.72作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验H2O:250mg/mL(336.60mM;Needultrasonic)DMSO:125mg/mL(168.30mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.3464mL6.7320mL13.4640mL5mM0.2693mL1.3464mL2.6928mL10mM0.1346mL0.6732mL1.3464mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Cidofovirdiphosphatetritriethylamine西多福韦的细胞内活性代谢物。diphosphatetritriethylamine是病毒DNA聚合酶的选择性抑制剂，对HCMV，HSV-1和HSV-2的Ki值分别为6.6，0.86和1.4μM。体外研究Cidofovirdiphosphatetritriethylamine(0-1000μM)inhibitsHCMV,HSV-1,HSV-2,humanα,humanβandhumanγDNApolymerasewithKivaluesof6.6,0.86,1.4,51,520and300μM,respectively[1].Cidofovirdiphosphatetritriethylamine(0.3-30μM)inhibitsvacciniavirusDNApolymerasewithaKmvalueof23μM1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[2].REFERENCES[1].HitchcockMJM,etal.Cidofovir,aNewAgentwithPotentAnti-HerpesvirusActivity.1996.[2].MageeWC,etal.MechanismofinhibitionofvacciniavirusDNApolymerasebycidofovirdiphosphate.AntimicrobAgentsChemother.2005Aug;49(8):3153-62.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792