Leukadherin-1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemELeukadherin-1Cat.No.:HY-15701CASNo.:344897-95-6分⼦式:C₂₂H₁₅NO₄S₂分⼦量:421.49作⽤靶点:Integrin;ComplementSystem作⽤通路:Cytoskeleton;Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:5mg/mL(11.86mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3725mL11.8627mL23.7254mL5mM0.4745mL2.3725mL4.7451mL10mM0.2373mL1.1863mL2.3725mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Leukadherin-1特异性的⽩细胞表整合素CD11b/CD18的激动剂。Leukadherin-1可增加CD11b/CD18依赖性细胞对⾎纤蛋⽩原的粘附，EC50为4μM。Leukadherin-1增强⽩细胞对配体(如ICAM-1)和⾎管内⽪的粘附，从⽽减少⽩细胞跨内⽪迁移和流⼊损伤部位。Leukadherin-1抑制先天性炎症信号转导。体外研究Leukadherin-1isaspecificagonistoftheleukocytesurfaceintegrinCD11b/CD18(αMβ2;CR3;Mac-1).1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemELeukadherin‐1pretreatmentreducessecretionofinterferon(IFN)‐γ,tumournecrosisfactor(TNF)andmacrophageinflammatoryprotein(MIP)‐1βbymonokine‐stimulatedNKcells.Leukadherin‐1pretreatmentalso

reducessecretionofIL‐1β,IL‐6andTNFbyToll‐likereceptor(TLR)‐2andTLR‐7/8‐stimulatedmonocytes[3].体内研究Leukadherin-1(1mg/kg;i.p.;twicedailyfor14days)isbeneficialinpreventinghyperoxia-inducedneonatallunginjury,anexperimentalmodelofbronchopulmonarydysplasia(BPD)[1].AnimalModel:NewbornSpragueDawleyratpups[1]Dosage:1mg/kgAdministration:I.p.;twicedailyfor14daysResult:Beneficialonpreventingthelunginflammatoryresponse,improvedalveolarizationandvasculardevelopment,andreducedpulmonaryvascularremodelingandPHinahyperoxia-inducedexperimentalmodelofBPD.REFERENCES[1].JagarapuJ,etal.EfficacyofLeukadherin-1inthePreventionofHyperoxia-InducedLungInjuryinNeonatalRats.AmJRespirCellMolBiol.2015;53(6):793-801.[2].MaiguelD,etal.Smallmolecule-mediatedactivationoftheintegrinCD11b/CD18reducesinflammatorydisease.SciSignal.2011;4(189):ra57.[3].RobertsAL,etal.Thecomplementreceptor3(CD11b/CD18)agonistLeukadherin-1suppresseshumaninnateinflammatorysignalling.ClinExpImmunol.2016;185(3):361-371.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearc