Ombitasvir-ABT-267-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEOmbitasvirCat.No.:HY-13997CASNo.:1258226-87-7Synonyms:ABT-267分⼦式:C₅₀H₆₇N₇O₈分⼦量:894.11作⽤靶点:HCV作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥33mg/mL(36.91mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM1.1184mL5.5922mL11.1843mL5mM0.2237mL1.1184mL2.2369mL10mM0.1118mL0.5592mL1.1184mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(2.80mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(2.80mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Ombitasvir⼀种HCVNS5A抑制剂，对HCV因型1-5和6a的EC50值分别为0.82-19.3pM和366pM。IC50&TargetEC50:0.82to19.3pM(HCVgenotypes1to5),366pM(HCVgenotype6a)[1]体外研究Ombitasvirisactiveagainstthegenotype2aJFH-1replicon,withanEC50of0.82pM,andtheEC50sofombitasvirare42pMand68pMagainsttheL28andF28variantsofthisgenotype6areplicon,respectively[1].InGT1a,variantsM28V,L31V,andH58Dconfers58-to243-foldresistancetoOmbitasvir.SinglevariantsM28T,Q30R,andY93C/Sconfers800-to8965-foldresistance,whileY93H/Nconfers>40000-foldresistancetoOmbitasvir[2].户使⽤本产品发表的科研⽂献•AntiviralRes.2017Mar;139:18-24.•JVirol.2018Jan2;92(2).pii:e01582-17.•ChemCentJ.2017Jan3;11:1.•Xenobiotica.2019Aug;49(8):935-944.•JLiqChromaTogrRT.2019:1-9.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KrishnanP,etal.Invitroandinvivoantiviralactivityandresistanceprofileofombitasvir,aninhibitorofhepatitisCvirusNS5A.AntimicrobAgentsChemother.2015Feb;59(2):979-87[2].DeGoeyDA,etal.DiscoveryofABT-267,apan-genotypicinhibitorofHCVNS5A.JMedChem.2014Mar13;57(5):2047-57McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch