Glycyrrhizic-acid-Glycyrrhizin-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGlycyrrhizicacidCat.No.:HY-N0184CASNo.:1405-86-3Synonyms:Glycyrrhizin分⼦式:C₄₂H₆₂O₁₆分⼦量:822.93作⽤靶点:VirusProtease作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:500mg/mL(607.59mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.2152mL6.0759mL12.1517mL5mM0.2430mL1.2152mL2.4303mL10mM0.1215mL0.6076mL1.2152mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥22.5mg/mL(27.34mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:10mg/mL(12.15mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:10mg/mL(12.15mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性Glycyrrhizicacid⽢草⾥的活性成分三萜皂苷，为HMGB1的拮抗剂，有⽤于肿瘤、糖尿病等研究的潜⼒。体外研究Glycyrrhizicacidshowsaseriesofanti-cancer-relatedpharmacologicalactivities,suchasbroad-spectrumanti-cancerability,resistancetothetissuetoxicitycausedbychemotherapyandradiation,drugabsorptionenhancingeffectsandanti-multidrugresistance(MDR)mechanisms,asacarriermaterialindrugdeliverysystems[1].InintestinalNCI-H716cellsthatsecretesGLP-1,GlycyrrhizicacidpromotesGLP-1secretionwithamarkedelevationofcalciumlevels.GlycyrrhizicacidcanenhanceGLP-1secretionthroughTGR5activation[2].Glycyrrhizicacidcanformastabletransparentlow-molecular-weighthydrogels(LMWHs)at37°Cinphysiologicalphosphatebufferedsaline(PBS)withnanoclustersasthemicrostructures[4].体内研究Intype1-likediabeticratsinducedbystreptozotocin(STZ-treatedrats),GlycyrrhizicacidincreasesthelevelofplasmaGLP-1,whichisblockedbytriamtereneatadosesufficienttoinhibitTakedaG-protein-coupledreceptor5(TGR5)[1].Glycyrrhizicacid(Glycyrrhizicacid;50mg/kg,i.p.)significantlydecreasesthelevelsofTgAb,HMGB1,TNF-α,IL-6,IL-1βinmice[3].PROTOCOLAnimalMice[3]Administration[3]NOD.H-2h4micearefedintheanimalhouseuntil4weeksofage.Atotalof24malemicearethenrandomlyseparatedintothreedifferentgroups(n=8pergroup).Miceinthecontrolgrouparegivensterilewaterwithoutsupplement.Miceintheiodinesupplement(NaI)grouparegiven0.005%NaIinthedrinkingwater.MiceintheNaI+Glycyrrhizicacidgrouparetreatedwith50mg/kgGlycyrrhizicacidoncedailyfor4weeks,administeredviaintraperitonealinjectionafter8weeksofiodinesupplementation.Thyroidtissuesareremovedsurgicallyunderanesthesia,washedwithcoldsaline,blottedonfilterpaperandweighedusinganelectronicbalance.Thethyroidglandtissuesarethenstoredat-80°Cuntiluse[3].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.户使⽤本产品发表的科研⽂献•CellProlif.2020Jun;53(6):e12829.•FrontCellDevBiol.2020Aug11;8:713.2/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE•ACSChemNeurosci.2020Mar18;11(6):979-993.•Aging(AlbanyNY).2019Jul7;11(13):4323-4337.•JFunctFoods.2021,104584.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SuX,etal.Glycyrrhizicacid:Apromisingcarriermaterialforanticancertherapy.BiomedPharmacother.2017Sep5;95:670-678[2].WangLY,etal.Glycyrrhizicacidincreasesglucagonlikepeptide-1secretionviaTGR5activationintype1-likediabeticrats.BiomedPharmacother.2017Sep4;95:599-604.[3].LiC,etal.Glycyrrhizin,aDirectHMGB1Antagonist,AmelioratesInflammatoryInfiltrationinaModelofAutoimmuneThyroiditisviaInhibitionofTLR2-HMGB1Signaling.Thyroid.2017May;27(5):722-731.[4].XiaZhao,etal.ASimpleInjectableMoldableHydrogelAssembledfromNaturalGlycyrrhizicAcidwithInherentAntibacterialActivity.ACSAppl.BioMater.2020,3,1,6