Neomycin-sulfate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENeomycinsulfateCat.No.:HY-B0470CASNo.:1405-10-3分⼦式:C₂₃H₅₂N₆O₂₅S₃分⼦量:908.88作⽤靶点:Bacterial;Antibiotic;Phospholipase作⽤通路:Anti-infection;MetabolicEnzyme/Protease储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验H2O:250mg/mL(275.06mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.1003mL5.5013mL11.0026mL5mM0.2201mL1.1003mL2.2005mL10mM0.1100mL0.5501mL1.1003mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：PBSSolubility:50mg/mL(55.01mM);Clearsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Neomycinsulfate⼀种氨糖苷类抗⽣素，通过核30S核糖体亚单位的不可逆结合发挥抗活性(antibacterial)，从⽽阻断细蛋⽩质的合成。Neomycinsulfate⼀种已知的磷脂酶C(PLC)抑制剂。Neomycinsulfate能抑制⾎管⽣成素的核转位和⾎管⽣成素诱导的细胞增殖和⾎管⽣成。IC50&TargetAminoglycoside体外研究Neomyciniseffectiveagainstmostgram-negativeorganismsexceptPseudomonasaeruginosaandanaerobicbacteria.Itsactivityagainstgram-positivemicroorganismsismoreorlesslimitedtostaphylococci,butbacterialresistancesupervenesafterprolongeduse[1].户使⽤本产品发表的科研⽂献•EmergMicrobesInfect.2022Feb22;1-34.•BrainBehavImmun.2020Nov24;S0889-1591(20)32408-9.•CellRep.2021Sep7;36(10):109660.•CellDeathDis.2021Jun7;12(6):582.•CellDeathDiscov.2022Feb22;8(1):77.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SassevilleD.Neomycin.Dermatitis.2010;21(1):3-7.[2].HuGF.Neomycininhibitsangiogenin-inducedangiogenesis.ProcNatlAcadSciUSA.1998;95(17):9791-9795.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: