R-BAY-85-8501-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(R)-BAY-85-8501Cat.No.:HY-19908BCASNo.:2446175-39-7分⼦式:C₂₂H₁₇F₃N₄O₃S分⼦量:474.46作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(210.77mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1077mL10.5383mL21.0766mL5mM0.4215mL2.1077mL4.2153mL10mM0.2108mL1.0538mL2.1077mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(5.27mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.27mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性(R)-BAY-85-8501BAY-85-8501活性较低的对映体。BAY-85-8501⼈类中性脂酶(HNE)的⼀个有效的、选择性抑制剂，其IC50值为65pM。户使⽤本产品发表的科研⽂献•ChineseAcademyofSciences.2019Aug.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].VonNussbaumF,etal.FreezingtheBioactiveConformationtoBoostPotency:TheIdentificationofBAY85-8501,aSelectiveandPotentInhibitorofHumanNeutrophilElastaseforPulmonaryDiseases.ChemMedChem.2015Jul;10(7):1163-73.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559