Stigmasterol-Stigmasterin-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEStigmasterolCat.No.:HY-N0131CASNo.:83-48-7Synonyms:Stigmasterin分⼦式:C₂₉H₄₈O分⼦量:412.69作⽤靶点:MMP;EndogenousMetabolite作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验Acetone:6.67mg/mL(16.16mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)1MNaOH:<1mg/mL(insoluble)Ethanol:<1mg/mL(insoluble)DMSO:<1mg/mL(insolubleorslightlysoluble)DMF:1mg/mL(2.42mM;ultrasonicandwarmingandheatto60°C)MEOH:<1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.4231mL12.1156mL24.2313mL5mM0.4846mL2.4231mL4.8463mL10mM0.2423mL1.2116mL2.4231mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Stigmasterol(Stigmasterin)⼀种植物性甾醇，不仅具有降低胆醇的活性，并且在风湿性疾病的研究中被评价为抗硬化因⼦。IC50&TargetHumanEndogenousMetabolite体外研究PreincubationofStigmasteroltoIL-1beta-treatedcellsshowssignificantreductionofMMP-3mRNAinhumanandmouse,MMP-3proteininmouse,MMP-13mRNAinmouseandhuman,ADAMTS-4mRNAinhuman,PGE2proteininhumanandmouse.StigmasterolisalsocapableofcounteractingtheIL-1beta-inducedNF-κBpathway[1].PROTOCOLCellAssay[1]Amodelofnewbornmousechondrocytesandhumanosteoarthritis(OA)chondrocytesareusedinprimaryculturestimulatedwithorwithoutIL-1β(10ng/mL),for18h.Cellsarepre-incubatedwithStigmasterol(20mg/mL)for48h[1].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.户使⽤本产品发表的科研⽂献•JEthnopharmacol.2022Aug2;115586.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GabayO,etal.Stigmasterol:aphytosterolwithpotentialanti-osteoarthriticproperties.OsteoarthritisCartilage.2010Jan;18(1):106-16.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: