2-Chloropyridin-4-yl-methanamine-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(2-Chloropyridin-4-yl)methanaminehydrochlorideCat.No.:HY-101771ACASNo.:916210-98-5分⼦式:C₆H₈Cl₂N₂分⼦量:179.05作⽤靶点:MonoamineOxidase作⽤通路:NeuronalSignaling储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验H2O:≥50mg/mL(279.25mM)DMSO:≥33mg/mL(184.31mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM5.5850mL27.9252mL55.8503mL5mM1.1170mL5.5850mL11.1701mL10mM0.5585mL2.7925mL5.5850mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：PBSSolubility:100mg/mL(558.50mM);Clearsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性(2-Chloropyridin-4-yl)methanaminehydrochloride选择性的LOXL2抑制剂，IC50值为126nM。IC50&TargetIC50:126nM(LOXL2)[1]体外研究(2-Chloropyridin-4-yl)methanaminehydrochlorideisshowntobeselectiveforLOXL2overLOXandthreeotheramineoxidases(MAO-A,MAO-BandSSAO).InthehumanwholebloodLOXL2assay,(2-Chloropyridin-4-yl)methanaminehydrochloridehasanIC50of1.45µMcomparedto126nMintheabsenceofbloodproteins.(2-Chloropyridin-4-yl)methanaminehydrochlorideshowsa31-foldselectivityforLOXL2+BSA(IC50=190nM)overLOX+BSA(IC50=5.91µM).Againstapanelofnon-LTQ-containingAOenzymes(MAO-A,MAO-BandSSAO),LOXL2-IN-1isfoundtobeinactiveat30µM.(2-Chloropyridin-4-yl)methanaminehydrochlorideisprofiledfortheinhibitionofthreedifferentCYPenzymes(CYPs3A4,2C9and2D6)andineachcasetheIC50ismorethan30µM[1].户使⽤本产品发表的科研⽂献•AgingCell.2022Jun17;e13659.•OncolRep.2020May;43(5):1641-1649.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HutchinsonJH,etal.SmallMoleculeLysylOxidase-like2(LOXL2)Inhibitors:TheIdentificationofanInhibitorSelectiveforLOXL2overLOX.ACSMedChemLett.2017Mar1;8(4):423-427.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea