Cintirorgon-LYC-55716-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECintirorgonCat.No.:HY-104037CASNo.:2055536-64-4Synonyms:LYC-55716分⼦式:C₂₇H₂₃F₆NO₆S分⼦量:603.53作⽤靶点:ROR作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥113.3mg/mL(187.73mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6569mL8.2846mL16.5692mL5mM0.3314mL1.6569mL3.3138mL10mM0.1657mL0.8285mL1.6569mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE1.请依序添加每种溶剂：5%DMSO>>40%PEG300>>5%Tween-80>>50%salineSolubility:≥2.5mg/mL(4.14mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Cintirorgon(LYC-55716)⼀种⾸创的、选择性的，具有⼝服活性的RORγ激动剂。Cintirorgon(LYC-55716)调节RORγ表达的T淋巴细胞免疫细胞的因表达，增强效应⼦功能，降低免疫抑制，降低肿瘤⽣长，提⾼⽣存率[1][2]。IC50&TargetRORγ[1]体内研究UponoraladministrationofRORγagonistCintirorgon(LYC-55716),thisagentselectivelybindstothenuclearreceptortranscriptionfactorRORγ,formingareceptorcomplexthattranslocatestothenucleus,andbindstoRORresponseelements(ROREs),enhancingthefunction,proliferationandsurvivaloftype17Tcells,includingTh17(helperTcells)andTc17(cytotoxicTcells).RORγ,thenuclearreceptortranscriptionfactorthatisinvolvedinTh17/Tc17differentiation,playsakeyroleinimmuneactivation.Cintirorgon(LYC-55716)isalsoorallybioavailable,whilethenewgenerationofimmuno-oncologydrugs-ncludingPD-1/PD-L1inhibitorsaredeliveredbyinjection[1].户使⽤本产品发表的科研⽂献•PharmacolRes.2021Jul30;105793.•EurJMedChem.2021,113585.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].LyceraAnnouncesInitiationofPhase1/2aStudyARGONofImmuno-OncologyCandidateLYC-55716inPatientswithAdvancedSolidTumors.Jan04,2017.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseo