DSP-4-hydrochloride-Neurotoxin-DSP-4-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDSP-4hydrochlorideCat.No.:HY-103210CASNo.:40616-75-9Synonyms:NeurotoxinDSP4hydrochloride分⼦式:C₁₁H₁₆BrCl₂N分⼦量:313.06作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:125mg/mL(399.28mM;Needultrasonic)H2O:50mg/mL(159.71mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.1943mL15.9714mL31.9428mL5mM0.6389mL3.1943mL6.3886mL10mM0.3194mL1.5971mL3.1943mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.08mg/mL(6.64mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(6.64mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(6.64mM);Clearsolution4.请依序添加每种溶剂：PBSSolubility:50mg/mL(159.71mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性DSP-4hydrochloride⼀种⾼度选择性的肾上腺素能神经毒素。DSP-4hydrochloride可以穿过⾎脑屏障。DSP-4hydrochloride可⽤于中枢和外周去甲肾上腺素能神经元的暂时选择性降解。体内研究DSP-4hydrochloride(i.p.;50mg/kg;single)destroystheLCneuronsandfibers[1].AnimalModel:rats[1]Dosage:50mg/kgAdministration:intraperitoneal,singleResult:NotvisualizedlargeprojectionneuronsandthefibersoftheLC.REFERENCES[1].HormigoS,etal.TheselectiveneurotoxinDSP-4impairsthenoradrenergicprojectionsfromthelocuscoeruleustotheinferiorcolliculusinrats.FrontNeuralCircuits.2012Jun28;6:41.[2].Jaim-EtcheverryG,etal.DSP-4:anovelcompoundwithneurotoxiceffectsonnoradrenergicneuronsofadultanddevelopingrats.BrainRes.1980Apr28;188(2):513-23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon