Propyl-pyrazole-triol-PPT-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPropylpyrazoletriolCat.No.:HY-100689CASNo.:263717-53-9Synonyms:PPT分⼦式:C₂₄H₂₂N₂O₃分⼦量:386.44作⽤靶点:EstrogenReceptor/ERR作⽤通路:Others储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥100mg/mL(258.77mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5877mL12.9386mL25.8772mL5mM0.5175mL2.5877mL5.1754mL10mM0.2588mL1.2939mL2.5877mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥10mg/mL(25.88mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.47mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.47mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Propylpyrazoletriol(PPT)⼀种选择性的雌激素受体α(ERα)激动剂。Propylpyrazoletriol(PPT)对ERα的相对结合亲和⼒(ERα:49%)雌激素受体β(ERβ:0.12%)的410倍[1]。IC50&TargetERα体外研究TheEC50ofPropylpyrazoletriolfortheERα-dependentresponseis140pMinERα-U2OS-Luccells[1].户使⽤本产品发表的科研⽂献•IntJBiolSci.2022;18(5):1961-1973.•CancerLett.2021Feb1;498:54-69.•JClinEndocrinolMetab.2021Feb1;dgab020.•JAgricFoodChem.2021Nov24.•MolNeurobiol.2022Sep2.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].InfluenceofcellularERalpha/ERbetaratioontheERalpha-agonistinducedproliferationofhumanT47Dbreastcancercells.[2].StaufferSR,etal.Pyrazoleligands:structure-affinity/activityrelationshipsandestrogenreceptor-alpha-selectiveagonists.JMedChem.2000Dec28;43(26):4934-47.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel