SMCC-DM1-DM1-SMCC-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESMCC-DM1Cat.No.:HY-101070CASNo.:1228105-51-8Synonyms:DM1-SMCC分⼦式:C₅₁H₆₆ClN₅O₁₆S分⼦量:1072.61作⽤靶点:Drug-LinkerConjugatesforADC作⽤通路:Antibody-drugConjugate/ADCRelated储存⽅式:-80°C,storedundernitrogen溶解性数据体外实验DMSO:16.67mg/mL(15.54mM;ultrasonicandwarmingandheatto80°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM0.9323mL4.6615mL9.3231mL5mM0.1865mL0.9323mL1.8646mL10mM0.0932mL0.4662mL0.9323mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months(storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2mg/mL(1.86mM);Clearsolution;Needultrasonic2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2mg/mL(1.86mM);Clearsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2mg/mL(1.86mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性SMCC-DM1(DM1-SMCC)由linkerSMCC和毒性分⼦DM1连接⽽成的，可⽤来制备抗体偶联药物。DM1(Mertansine)，含硫醇的美登⽊素⽣物碱，⼀种有效的微管破坏剂[1]。IC50&TargetMaytansinoids体外研究SMCC-DM1inhibitsHCC1954andMDA-MB-468cellsproliferationwithIC50sof17.2and49.9nM,respectively[1].户使⽤本产品发表的科研⽂献•MolTher.2022Apr18;S1525-0016(22)00237-4.•CancerLett.2022:216024.•Mbio.2022Jan18;e0338421.•IntJMolSci.2022,23(20),12358.•MonoclonAntibImmunodiagnImmunother.2020Apr;39(2):37-44.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ShaoS,etal.Site-specificandhydrophilicADCsthroughdisulfide-bridgedlinkerandbranchedPEG.BioorgMedChemLett.2018May1;28(8):1363-1370.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-