MIK665-S-64315-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMIK665Cat.No.:HY-112218CASNo.:1799631-75-6Synonyms:S-64315分⼦式:C₄₇H₄₄ClFN₆O₆S分⼦量:875.41作⽤靶点:Bcl-2Family作⽤通路:Apoptosis储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥125mg/mL(142.79mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM1.1423mL5.7116mL11.4232mL5mM0.2285mL1.1423mL2.2846mL10mM0.1142mL0.5712mL1.1423mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(2.38mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(2.38mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性MIK665(S-64315)，于S63845，⼀种髓系细胞⽩⾎病序列1(MCL1)抑制剂，对MCL1的IC50为1.81nM[1]。IC50&TargetMcl-11.81nM(IC50)体外研究MIK665(S-64315)hassimilarsynergisticeffectsasS63845,whencombinedwithABT-199.ThecombinationS64315(0.156-10μM)andABT-199(625nM)hassimilarefficacyinreducingthecellviabilityofrepresentativemelanomalines(MB2141,MB3616,MB3961,MB4667,A375,and1205Lucells)[1].MIK665isextractedfrompatentWO2016207225A1,compoundPreparation13,andinhibitsH929cellwithanIC50of250nM[2].户使⽤本产品发表的科研⽂献•CancerLett.2022Nov30;216028.•CellDeathDis.2020Jun8;11(6):443.•JInvestDermatol.2021Dec20;S0022-202X(21)02617-8.•Cancers.2020Aug5;12(8):2182.•Pharmaceuticals.2021,14(8),749.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ZoltánSZLÁVIK,etal.Newhydroxyesterderivatives,aprocessfortheirpreparationandpharmaceuticalcompositionscontainingthem.WO2016207225A1.[2].MukherjeeN,etal.SimultaneouslyInhibitingBCL2andMCL1IsaTherapeuticOptionforPatientswithAdvancedMelanoma.Cancers(Basel).2020;12(8):2182.Published2020Aug5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchu