plus-JQ1-PA-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(+)-JQ1PACat.No.:HY-112789CASNo.:2115701-93-2分⼦式:C₂₂H₂₀ClN₅OS分⼦量:437.95作⽤靶点:EpigeneticReaderDomain作⽤通路:Epigenetics储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验Ethanol:50mg/mL(114.17mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2834mL11.4168mL22.8337mL5mM0.4567mL2.2834mL4.5667mL10mM0.2283mL1.1417mL2.2834mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性(+)-JQ1PA溴结构域和额外末端结构域(BET)抑制剂JQ1的衍⽣物，其IC50值为10.4nM。IC50&Target10.4nM(BET)[1].体外研究(+)-JQ1PAisaderivativeofJQ1,whichistheinhibitorofBET.TheIC50of(+)-JQ1PAforBETis10.4nM,1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEandtheIC50ofJQ1is14.3nMinMV4;11cells[1].PROTOCOLCellAssay[1]ProliferationofMV4;11cellsafter72hoursoftreatment,comparingJQ1versusJQ1-PAaretested.CellcycleprofileofMV4;11cellsafter48hoursoftreatmentwithDMSO,JQ1,JQ1-PA,orJQ1-TCO(allcompoundsusedat500nM)aretested[1].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.REFERENCES[1].TylerDS,etal.Clickchemistryenablespreclinicalevaluationoftargetedepigenetictherapies.Science.2017Jun30;356(6345):1397-1401.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>