Pomalidomide-PEG4-azide-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPomalidomide-PEG4-azideCat.No.:HY-141015CASNo.:2271036-47-4分⼦式:C₂₃H₃₀N₆O₈分⼦量:518.52作⽤靶点:E3LigaseLigand-LinkerConjugates作⽤通路:PROTAC储存⽅式:-20°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:33.33mg/mL(64.28mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.9286mL9.6428mL19.2857mL5mM0.3857mL1.9286mL3.8571mL10mM0.1929mL0.9643mL1.9286mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(4.82mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Pomalidomide-PEG4-azide⼀种合成的E3连接酶配体-linker偶联物，包含于Pomalidomide的cereblon配体和1个linker[1]。IC50&TargetCereblon体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemtoselectivelydegradetargetproteins[1].REFERENCES[1].AnS,etal.Small-moleculePROTACs:Anemergingandpromisingapproachforthedevelopmentoftargetedtherapydrugs.EBioMedicine.2018Oct;36:553-562McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58