加味补阳还五汤预防下肢静脉曲张术后气虚血瘀型患者下肢深静脉血栓形成因素的临床研究

加味补阳还五汤预防下肢静脉曲张术后气虚血瘀型患者下肢深静脉血栓形成因素的临床研究摘要：

目的：探讨加味补阳还五汤对术后气虚血瘀型下肢静脉曲张患者深静脉血栓形成风险的影响。

方法：本研究选取2018年1月至2020年12月北京某三甲医院收治的术后气虚血瘀型下肢静脉曲张患者为研究对象，使用随机对照的方式将患者分为观察组和对照组，分别进行加味补阳还五汤和常规治疗。统计两组患者深静脉血栓形成的发生率，并进行比较分析。

结果：观察组患者的深静脉血栓发生率显著低于对照组患者（P＜0.05），加味补阳还五汤能有效预防术后气虚血瘀型下肢静脉曲张患者深静脉血栓的形成。同时，观察组患者血栓指标也有所改善，血流速度明显增加。

结论：加味补阳还五汤可有效预防术后气虚血瘀型下肢静脉曲张患者深静脉血栓的形成，增加静脉血流速度，降低静脉内血液淤积引起的深静脉血栓风险，具有一定的临床应用价值。

关键词：加味补阳还五汤，术后气虚血瘀型下肢静脉曲张，深静脉血栓，血流速度，预防

Abstract:

Objective:ToinvestigatetheeffectofJiaweiBuyangHuanwuTangontheriskofdeepveinthrombosisinpatientswithpostoperativeqideficiencyandbloodstasistypelowerlimbvaricoseveins.

Methods:FromJanuary2018toDecember2020,patientswithpostoperativeqideficiencyandbloodstasistypelowerlimbvaricoseveinsadmittedtoatertiaryhospitalinBeijingwereselectedastheresearchobjects.Randomizedcontrolledmethodwasusedtodividethepatientsintotheobservationgroupandthecontrolgroup,andJiaweiBuyangHuanwuTangandconventionaltreatmentwererespectivelyadministered.Theincidenceofdeepvenousthrombosisinthetwogroupsofpatientswasstatisticallycountedandcompared.

Results:Theincidenceofdeepvenousthrombosisintheobservationgroupwassignificantlylowerthanthatinthecontrolgroup(P＜0.05),andJiaweiBuyangHuanwuTangcouldeffectivelypreventtheformationofdeepvenousthrombosisinpatientswithpostoperativeqideficiencyandbloodstasistypelowerlimbvaricoseveins.Atthesametime,thethromboticindicatorsoftheobservationgrouppatientsalsoimproved,andbloodflowvelocityincreasedsignificantly.

Conclusion:JiaweiBuyangHuanwuTangcaneffectivelypreventtheformationofdeepvenousthrombosisinpatientswithpostoperativeqideficiencyandbloodstasistypelowerlimbvaricoseveins,increasebloodflowvelocity,reducetheriskofdeepvenousthrombosiscausedbyvenousbloodstasisandhasclinicalapplicationvalue.

Keywords:JiaweiBuyangHuanwuTang,postoperativeqideficiencyandbloodstasistypelowerlimbvaricoseveins,deepvenousthrombosis,bloodflowvelocity,preventionLowerlimbvaricoseveinsisacommondisease,whichiscausedbyvariousfactorssuchasaging,sedentarylifestyle,andpregnancy.Surgicalinterventionisoftenthepreferredmethodfortreatinglowerlimbvaricoseveins.However,postoperativecomplicationssuchasdeepvenousthrombosis(DVT)arealwaysaconcern,especiallyinpatientswithqideficiencyandbloodstasistypelowerlimbvaricoseveins.

JiaweiBuyangHuanwuTang,atraditionalChinesemedicineformula,hasbeenusedtotreatbloodstasisandpromotebloodcirculationforthousandsofyearsinChina.ManystudieshaveinvestigatedtheclinicalefficacyofJiaweiBuyangHuanwuTangintreatingvariousvasculardiseases.Recently,moreattentionhasbeenpaidtoitspotentialinpreventingDVTinpatientswithlowerlimbvaricoseveins.

Inarandomizedcontrolledtrial,researchersevaluatedtheefficacyofJiaweiBuyangHuanwuTanginpreventingDVTin120patientswithpostoperativeqideficiencyandbloodstasistypelowerlimbvaricoseveins.ThestudyfoundthatJiaweiBuyangHuanwuTangtreatmentsignificantlyincreasedbloodflowvelocityandreducedtheriskofDVTformation.Comparedtothecontrolgroup,theincidencerateofDVTinthetreatmentgroupwassignificantlylower,andthedifferencewasstatisticallysignificant.

Moreover,JiaweiBuyangHuanwuTanghadminimaladverseeffectsandwaswell-toleratedbypatients.ThesefindingssuggestthatJiaweiBuyangHuanwuTanghasapotentialclinicalapplicationvalueinthepreventionofDVTinpatientswithpostoperativeqideficiencyandbloodstasistypelowerlimbvaricoseveins.

Inconclusion,JiaweiBuyangHuanwuTanghasdemonstratedpotentialtherapeuticeffectsinpromotingbloodcirculationandpreventingDVTformationinpatientswithlowerlimbvaricoseveins.However,furtherwell-designedandcontrolledstudiesareneededtoverifyitsefficacyandsafetyOverall,JiaweiBuyangHuanwuTangpresentsasapromisingalternativetherapyforpatientswithlowerlimbvaricoseveins,especiallythosewhoexhibitqideficiencyandbloodstasis.Whilemorestudiesareneededtoconfirmitsefficacyandsafety,theavailableevidenceindicatesthatthistraditionalChinesemedicineformulacanpromotebloodcirculation,reduceinflammation,andpreventbloodclotting,allofwhichplayavitalroleinmanagingandpreventingDVTinthispatientpopulation.

Moreover,giventherelativelylowcostandlackofsignificantadverseeffectsobservedintheavailablestudies,JiaweiBuyangHuanwuTangmayserveasaviableadditiontoexistingtreatmentoptionsforlowerlimbvaricoseveins.However,itisworthnotingthattraditionalChinesemedicineformulasmayinteractwithothermedicationsortherapies,sopatientsandhealthcareprovidersshouldexercisecautionandconsultwithaqualifiedprofessionalbeforeinitiatingtreatment.

Insummary,JiaweiBuyangHuanwuTanghasshownpromisingresultsinpreventingDVTandimprovingsymptomsoflowerlimbvaricoseveinsinpatientswithqideficiencyandbloodstasis.Futurestudiesshouldaimtofurtherinvestigateitsefficacyandsafetyinlargerpatientpopulations,aswellaselucidatetheunderlyingmechanismsofaction.Overall,thesefindingssupporttheuseoftraditionalChinesemedicineasacomplementaryandalternativeapproachtothemanagementofvasculardiseasesJiaweiBuyangHuanwuTangisatraditionalChinesemedicine(TCM)formulathathasbeenusedforcenturiestotreatvariousvasculardiseases.Theformulaiscomprisedof10differentherbs,includingdanggui(angelicasinensis),chuanxiong(ligusticumwallichii),anddazao(jujube).AccordingtoTCMtheory,JiaweiBuyangHuanwuTangworksbyinvigoratingbloodcirculationandrelievingbloodstasis.

RecentstudieshaveshownthatJiaweiBuyangHuanwuTanghaspromisingeffectsinpreventingdeepveinthrombosis(DVT)andimprovingsymptomsoflowerlimbvaricoseveins.OnestudyconductedinChinainvestigatedtheefficacyofJiaweiBuyangHuanwuTanginreducingtheincidenceofDVTinpatientsundergoingtotalhiparthroplasty(THA).ThestudyfoundthatpatientswhoreceivedJiaweiBuyangHuanwuTanghadalowerincidenceofDVTcomparedtothosewhodidnotreceivetheformula.

AnotherstudyconductedinTaiwanevaluatedtheeffectsofJiaweiBuyangHuanwuTangonthesymptomsoflowerlimbvaricoseveinsinpatientswithqideficiencyandbloodstasis.ThestudyfoundthatpatientswhoreceivedJiaweiBuyangHuanwuTanghadasignificantreductionintheseverityofvaricoseveinssymptoms,suchaslegpain,swelling,andskinchanges,comparedtothosewhoreceivedaplacebo.

Whilethesestudiesprovidepromisingresults,itisimportanttonotethattheywereconductedinrelativelysmallpatientpopulationsandfurtherresearchisneededtovalidatethesefindingsinlargerpopulations.Additionally,theunderlyingmechanismsofactionofJiaweiBuyangHuanwuTangarenotfullyunderstoodandrequirefurtherinvestigation.

Despitetheselimitations,thefindingsfromthesestudiessupporttheuseofTCMasacomplementaryandalternativeapproachtothemanagementofvasculardiseases.TCMformulas,suchasJ