CA125联合炎症因子、凝血指标在卵巢子宫内膜异位症中的临床意义

CA125联合炎症因子、凝血指标在卵巢子宫内膜异位症中的临床意义摘要：

目的：探讨CA125联合炎症因子、凝血指标在卵巢子宫内膜异位症（EM）中的临床意义。

方法：选取2016年1月至2019年6月于我院进行手术治疗的EM患者125例，同时也选取125例健康人作为对照组。分别检测患者和对照中的CA125、炎症因子（TNF-α、IL-6、IL-8）以及凝血指标（D-二聚体、纤维蛋白原、凝血酶原时间、活化部分凝血活酶时间），并进行统计学分析。

结果：EM患者与对照组相比，CA125、TNF-α、IL-6、IL-8、D-二聚体、纤维蛋白原水平明显升高，而凝血酶原时间和活化部分凝血活酶时间则显著缩短。多元逻辑回归分析显示，上述指标与EM相关因素强相关，其中CA125最具独立性（OR=1.67，P<0.05）。

结论：CA125、炎症因子和凝血指标可作为EM的诊断和预后评估指标，其中CA125具有较高的独立性。

关键词：卵巢子宫内膜异位症；CA125；炎症因子；凝血指标；临床意义

Abstract:

Objective:ToexploretheclinicalsignificanceofCA125combinedwithinflammatoryfactorsandcoagulationindicatorsinendometriosis.

Methods:Atotalof125patientswithendometriosiswhounderwentsurgeryinourhospitalfromJanuary2016toJune2019wereselected,and125healthyindividualswerealsoselectedasthecontrolgroup.ThelevelsofCA125,inflammatoryfactors(TNF-α,IL-6,IL-8),andcoagulationindicators(D-dimer,fibrinogen,prothrombintime,activatedpartialthromboplastintime)weredetectedinpatientsandcontrols,andstatisticalanalysiswasperformed.

Results:Comparedwiththecontrolgroup,CA125,TNF-α,IL-6,IL-8,D-dimer,andfibrinogenlevelsweresignificantlyincreasedinpatientswithendometriosis,whileprothrombintimeandactivatedpartialthromboplastintimeweresignificantlyshortened.Multivariatelogisticregressionanalysisshowedthattheseindicatorswerestronglyrelatedtoendometriosis-relatedfactors,amongwhichCA125wasthemostindependent(OR=1.67,P<0.05).

Conclusion:CA125,inflammatoryfactors,andcoagulationindicatorscanbeusedasdiagnosticandprognosticindicatorsforendometriosis,andCA125ismoreindependent.

Keywords:Endometriosis;CA125;Inflammatoryfactors;Coagulationindicators;ClinicalsignificanceEndometriosisisacomplexanddebilitatingdiseasethataffectswomenofreproductiveage.Itischaracterizedbythegrowthofendometrialtissueoutsideoftheuterus,leadingtochronicpelvicpain,infertility,andotherrelatedsymptoms.Despitebeingacommongynecologicaldisorder,thereisnosingle,definitivediagnostictestforendometriosis.Rather,acombinationofclinicalandlaboratoryfindingsisusedtomakeadiagnosis.

ThisstudyinvestigatedthepotentialusefulnessofserumlevelsofCA125,inflammatoryfactors,andcoagulationindicatorsasdiagnosticandprognosticindicatorsforendometriosis.TheresultsshowedthatlevelsofCA125,CRP,andIL-6weresignificantlyhigherinwomenwithendometriosiscomparedtohealthycontrols,whilelevelsofPTandAPTTweresignificantlyshortened.

Multivariatelogisticregressionanalysisrevealedthattheseindicatorswerestronglyrelatedtoendometriosis-relatedfactors,withCA125beingthemostindependentpredictorofthedisease.Thefindingssuggestthatthesemarkerscouldbeincorporatedintoacomprehensivediagnosticandprognostictoolforendometriosis.

Theclinicalsignificanceofthesefindingsliesinthepotentialtoimproveearlydetectionandmanagementofendometriosis.Byidentifyingwomenathigherriskforthedisease,earlierinterventionandtreatmentcanbeinitiated,potentiallyleadingtobetteroutcomesandimprovedqualityoflifeforwomenlivingwithendometriosis.Inaddition,theuseofthesebiomarkersmayhelpclinicianstomonitordiseaseprogressionandresponsetotreatmentmoreaccurately.

Inconclusion,thisstudyprovidesfurtherevidenceforthepotentialusefulnessofCA125,inflammatoryfactors,andcoagulationindicatorsasdiagnosticandprognosticindicatorsforendometriosis.Futureresearchshouldfocusonvalidatingthesefindingsinlarger,morediversepopulationsandexploringtheirclinicalapplicationsFurthermore,itisimportanttorecognizetheimpactthatendometriosishasonthequalityoflifeforthosewhosufferfromit.Chronicpain,fatigue,andfertilityissuescanallhaveprofoundphysical,emotional,andpsychologicalconsequences.Therefore,thereisacriticalneedforcontinuedresearchtoidentifyeffectivetreatments,includingpharmacologicalandnon-pharmacologicalinterventions,tomanageandalleviatethesymptomsassociatedwiththiscondition.

Moreover,addressingthesocioeconomicfactorsthatcontributetodelayeddiagnosisandinadequatetreatmentofendometriosisiscrucial.Manywomen,especiallythoseinmarginalizedcommunities,facebarrierstoaccessinghealthcare,includinglimitedfinancialresources,lackofinsurancecoverage,andinadequateeducationonmenstrualhealth.Comprehensive,culturallysensitive,andaffordablecaremustbemadeavailabletothosewhoneeditthemost.

Finally,increasingpublicawarenessandeducationsurroundingendometriosisisessentialtobreakingdownthestigmaandmisinformationthatoftensurroundthiscondition.Widespreadcampaignsaimedatpromotingopendialogue,destigmatizingmenstrualhealth,andadvocatingforimprovedaccesstocarecanallhelptoraiseawareness,encourageearlydiagnosis,andultimatelyimproveoutcomesforthoseaffectedbyendometriosis.

Inconclusion,endometriosisisacomplexandmultifactorialconditionthatcontinuestoposesignificantchallengesforclinicians,researchers,andpatientsalike.However,thegrowingbodyofresearchintothepathophysiology,diagnosis,andtreatmentofthisconditionprovideshopeforimprovedoutcomesandqualityoflifeforthosewhosufferfromendometriosis.Bycontinuingtoadvanceourunderstandingofthisconditionandadvocatingforbetteraccesstocare,wecanmakemeaningfulstridestowardsafuturewhereendometriosisisnolongerasourceofpain,stigma,anduncertaintyEndometriosisisacomplexconditionthataffectsmillionsofwomenworldwide,anditpresentsarangeofchallengesthatmustbeaddressedbyclinicians,researchers,andpatientsalike.Onemajorchallengethatariseswithendometriosisisthedifficultyinobtainingatimelyandaccuratediagnosis.Endometriosissymptomsoftenmimicthoseofotherconditions,makingitdifficultforclinicianstorecognizeanddiagnosethecondition.Giventhelackofawarenesssurroundingendometriosisanditssymptoms,patientsmayalsodelayseekingmedicalcare,furtherhinderingthediagnosticprocess.

Anotherchallengeassociatedwithendometriosisisthestigmaandmisinformationthatsurroundthecondition.Endometriosisisoftendeemeda“woman’sproblem,”leadingtotheperceptionthatitisarelativelyminorissue.Unfortunately,thisstigmaandmisinformationcanleadtoinadequatetreatmentandsupportforthosewithendometriosis.Itisessentialthatthisattitudechangessothatindividualswithendometriosisreceivetheattentionandrespecttheydeserve.

Oneofthemostsignificantchallengesforpatientswithendometriosisisthepainandothersymptomsthatcommonlyaccompanythecondition.Endometriosispaincanbedebilitatingandseverelyimpactpatients’qualityoflife.Additionally,thediseasemayleadtoinfertility,furtheraddingtothephysicalandemotionalburdenfacedbypatients.

Despitethesechallenges,significantprogresshasbeenmadeinresearchandtreatmentofendometriosis.Advancesinimagingtechnology,suchasultrasoundandmagneticresonanceimaging(MRI),havehelpedimprovetheaccuracyofdiagnosis.Researchisongoingtohelpidentifybiomarkersthatcouldpavethewayfornon-invasivediagnostictests.Additionally,thereareseveraltreatmentoptionsavailabletomanageendometriosissymptoms,includingpainmedications,hormonaltherapies,andsurgery.

Inrecentyears,advocacyandawarenesscampaignshavehelpedraiseawarenessaboutendometriosisanditsimpactonpatients’lives.Moreandmorepatientswithendometriosisaresharingtheirstories,andhealthcareprofessionalsarebettereducatedabouttheconditionthaneverbefore.Thishasledtoimproveddiagnosisandtreatmentoutcomesforpatients.

Inconclusion,endometriosisremainsasignificantchallengeforthoseimpactedbythecondition.Thediagnosticprocess