Crisnatol-BWA770U-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECrisnatolCat.No.:HY-108999ACASNo.:96389-68-3Synonyms:BWA770U分⼦式:C₂₃H₂₃NO₂分⼦量:345.43作⽤靶点:DNA/RNASynthesis作⽤通路:CellCycle/DNADamage储存⽅式:4°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性数据体外实验DMSO:100mg/mL(289.49mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8949mL14.4747mL28.9494mL5mM0.5790mL2.8949mL5.7899mL10mM0.2895mL1.4475mL2.8949mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Crisnatol(BWA770U)⼀种⼝服有效的抗癌剂和芳甲氨丙⼆醇类DNA插⼊器。Crisnatol对⼈类乳腺癌细胞显⽰出体外细胞毒性，但对正常的⼈类⽪肤成纤维细胞⽆效。体外研究Crisnatol(1.3μg/mL;24-72h)inhibitsthereplicationofHepG2cells,decreasescellviabilityby35%[2].CellViabilityAssay[2]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECellLine:HepG2cellsConcentration:1.3μg/mLIncubationTime:24hours,48hours,72hours,and126hoursResult:Inhibitedcellviabilityat48hr.体内研究Crisnatol(25mg/kg;p.o.;singledose)showsoralactivityandshowsstablemetaboliteprofileextractofratfecesbyautoradiography[2].REFERENCES[1].AdamsDJ.Invitropharmacodynamicassayforcancerdrugdevelopment:applicationtocrisnatol,anewDNAintercalator.CancerRes.1989Dec1;49(23):6615-20.[2].PatelDK,etal.Metabolismofanovelantitumoragent,crisnatol,byahumanhepatomacellline,HepG2,andhepaticmicrosomes.Characterizationofmetabolites.BiochemPharmacol.1991Jul5;42(2):337-46.[3].PatelDK,etal.Disposition,metabolism,andexcretionoftheanticanceragentcrisnatolintherat.DrugMetabDispos.1991Mar-Apr;19(2):491-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82