ALW-II-49-7-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEALW-II-49-7Cat.No.:HY-18833CASNo.:1135219-23-6分⼦式:C₂₁H₁₇F₃N₄O₂分⼦量:414.38作⽤靶点:EphrinReceptor作⽤通路:ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:100mg/mL(241.32mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.4132mL12.0662mL24.1324mL5mM0.4826mL2.4132mL4.8265mL10mM0.2413mL1.2066mL2.4132mL体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(6.03mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.03mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.03mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性ALW-II-49-7⼀种选择性的EphB2抑制剂，细胞内的EC50为40nM。IC50&TargetEphB2[1]体外研究ALW-II-49-7(compound9)exhibitsselectivityprofileofbindingtoasetofkinasesincludingb-raf,CSF1R,DDR1,DDR2,EphA2,EphA5,EphA8,EphB1,EphB2,EphB3,Frk,Kit,Lck,p38a,p38b,PDGFRa,PDGFRb,andRaf1[1].ALW-II-49-7(0.01-10μM;1h)inhibitsEphB2tyrosinekinaseactivityinU87glioblastomacells.EphB2isaddedinmediaat2μg/mL[1].REFERENCES[1].ChoiY,etal.DiscoveryandstructuralanalysisofEphreceptortyrosinekinaseinhibitors.BioorgMedChemLett.2009Aug1;19(15):4467-70.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021