Lenaldekar-LDK-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemELenaldekarCat.No.:HY-121662CASNo.:418800-15-4Synonyms:LDK分子式:C₁₈H₁₄N₄分子量:286.33作用靶点:Apoptosis作用通路:Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Lenaldekar(LDK)抑制人类和小鼠T细胞扩增。Lenaldekar抑制自身免疫T细胞反应。Lenaldekar还可诱导癌细胞凋亡(apoptosis)。Lenaldekar可用于T细胞介导的自身免疫性疾病研究。体外研究Lenaldekar(4days)inhibitsCD3+Tcellproliferationinadose-dependentmannerwithanIC50of3μM[1].Lenaldekar(3μM,4days)reducesamemoryTcellresponsetoinfluenzaantigenH3[1].Lenaldekar(48h)showscytotoxicityinJurkatT-ALLcell,withIC50sof0.8μM,andinducesapoptosis(1μM)[2].体内研究Lenaldekar(40mg/kgperday,i.p.)inhibitsexperimentalautoimmuneencephalomyelitis(EAE)relapseinmicesensitizedwiththeencephalitogenicPLP139-151peptide[1].Lenaldekar(16mg/kg,i.p.,twicedaily)inhibitstumorprogessioninamousexenograftmodelofT-cellacutelymphoblasticleukemia(T-ALL)[2].REFERENCESCusickMF,etal.HumanTcellexpansionandexperimentalautoimmuneencephalomyelitisinhibitedbyLenaldekar,asmallmoleculediscoveredinazebrafishscreen.JNeuroimmunol.2012Mar;244(1-2):35-44.RidgesS,etal,etal.Zebrafishscreenidentifiesnovelcompoundwithselectivetoxicityagainstleukemia.Blood.2012Jun14;119(24):5621-31.McePdfHeight1/1 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>