常用的meta分析文献质量评价量表：AMSTAR-Checklist-for-系统综述质量评价

AMSTARChecklist

ArticleName:

1.DidtheresearchquestionsandinclusioncriteriaforthereviewincludethecomponentsofPICO?

ForYes:

Optional(recommended)

Population

Timeframeforfollowup

Yes

No

Intervention

Comparatorgroup

Outcome

2.Didthereportofthereviewcontainanexplicitstatementthatthereviewmethodswereestablishedpriortotheconductofthereviewanddidthereportjustifyanysignificantdeviationsfromtheprotocol?

ForPartialYes:

TheauthorsstatethattheyhadawrittenprotocolorguidethatincludedALLthefollowing:

ForYes:

Asforpartialyes,plustheprotocolshouldberegisteredandshouldalsohavespecified:

reviewquestion(s)

ameta-analysis/synthesisplan,ifappropriate,and

Yes

PartialYes

No

asearchstrategy

aplanforinvestigatingcausesofheterogeneity

inclusion/exclusioncriteria

aplanforinvestigatingcausesofheterogeneity

ariskofbiasassessment

3.Didthereviewauthorsexplaintheirselectionofthestudydesignsforinclusioninthereview?

ForYes,thereviewshouldsatisfyONEofthefollowing:

ExplanationforincludingonlyRCTs

Yes

No

ORExplanationforincludingonlyNRSI

ORExplanationforincludingbothRCTsandNRSI

4.Didthereviewauthorsuseacomprehensiveliteraturesearchstrategy?

ForPartialYes(allthefollowing):

ForYes,shouldalsohave(allthefollowing):

searchedatleast2databases(relevanttoresearchquestion)

searchedthereferencelists/bibliographiesofincludedstudies

Yes

PartialYes

No

providedkeywordand/orsearchstrategy

searchedtrial/studyregistries

justifiedpublicationrestrictions(e.g.language)

included/consultedcontentexpertsinthefield

whererelevant,searchedforgreyliterature

conductedsearchwithin24monthsofcompletionofthereview

5.Didthereviewauthorsperformstudyselectioninduplicate?

ForYes,eitherONEofthefollowing:

atleasttworeviewersindependentlyagreedonselectionofeligiblestudiesandachievedconsensusonwhichstudiestoinclude

Yes

No

ORtworeviewersselectedasampleofeligiblestudiesandachievedgoodagreement(atleast80percent),withtheremainderselectedbyonereviewer.

6.Didthereviewauthorsperformdataextractioninduplicate?

ForYes,eitherONEofthefollowing:

atleasttworeviewersachievedconsensusonwhichdatatoextractfromincludedstudies

Yes

No

ORtworeviewersextracteddatafromasampleofeligiblestudiesandachievedgoodagreement(atleast80percent),withtheremainderextractedbyonereviewer.

7.Didthereviewauthorsprovidealistofexcludedstudiesandjustifytheexclusions?

ForPartialYes:

ForYes,mustalsohave:

providedalistofallpotentiallyrelevantstudiesthatwerereadinfull-textformbutexcludedfromthereview

Justifiedtheexclusionfromthereviewofeachpotentiallyrelevantstudy

Yes

PartialYes

No

8.Didthereviewauthorsdescribetheincludedstudiesinadequatedetail?

ForPartialYes(ALLthefollowing):

ForYes,shouldalsohaveALLthefollowing:

describedpopulations

describedpopulationindetail

Yes

PartialYes

No

describedinterventions

describedinterventionindetail(includingdoseswhererelevant)

describedcomparators

describedcomparatorindetail(includingdoseswhererelevant)

describedoutcomes

describedstudy’ssetting

describedresearchdesigns

timeframeforfollow-up

9.Didthereviewauthorsuseasatisfactorytechniqueforassessingtheriskofbias(RoB)inindividualstudiesthatwereincludedinthereview?

RCTs

ForPartialYes,musthaveassessedRoBfrom

ForYes,mustalsohaveassessedRoBfrom:

unconcealedallocation,and

allocationsequencethatwasnottrulyrandom,and

Yes

PartialYes

No

IncludesonlyNRSI

lackofblindingofpatientsandassessorswhenassessingoutcomes(unnecessaryforobjectiveoutcomessuchasall-causemortality)

selectionofthereportedresultfromamongmultiplemeasurementsoranalysesofaspecifiedoutcome

NRSI

ForPartialYes,musthaveassessedRoB:

ForYes,mustalsohaveassessedRoB:

fromconfounding,and

methodsusedtoascertainexposuresandoutcomes,and

Yes

PartialYes

No

IncludesonlyRCTs

fromselectionbias

selectionofthereportedresultfromamongmultiplemeasurementsoranalysesofaspecifiedoutcome

10.Didthereviewauthorsreportonthesourcesoffundingforthestudiesincludedinthereview?

ForYes

Musthavereportedonthesourcesoffundingforindividualstudiesincludedinthereview.Note:Reportingthatthereviewerslookedforthisinformationbutitwasnotreportedbystudyauthorsalsoqualifies

Yes

No

11.Ifmeta-analysiswasperformeddidthereviewauthorsuseappropriatemethodsforstatisticalcombinationofresults?

RCTs

ForYes:

Theauthorsjustifiedcombiningthedatainameta-analysis

Yes

No

Nometa-analysisconducted

ANDtheyusedanappropriateweightedtechniquetocombinestudyresultsandadjustedforheterogeneityifpresent.

ANDinvestigatedthecausesofanyheterogeneity

ForNRSI

ForYes:

Theauthorsjustifiedcombiningthedatainameta-analysis

Yes

No

Nometa-analysisconducted

ANDtheyusedanappropriateweightedtechniquetocombinestudyresults,adjustingforheterogeneityifpresent

ANDtheystatisticallycombinedeffectestimatesfromNRSIthatwereadjustedforconfounding,ratherthancombiningrawdata,orjustifiedcombiningrawdatawhenadjustedeffectestimateswerenotavailable

ANDtheyreportedseparatesummaryestimatesforRCTsandNRSIseparatelywhenbothwereincludedinthereview

12.Ifmeta-analysiswasperformed,didthereviewauthorsassessthepotentialimpactofRoBinindividualstudiesontheresultsofthemeta-analysisorotherevidencesynthesis?

ForYes:

includedonlylowriskofbiasRCTs

Yes

No

Nometa-analysisconducted

OR,ifthepooledestimatewasbasedonRCTsand/orNRSIatvariableRoB,theauthorsperformedanalysestoinvestigatepossibleimpactofRoBonsummaryestimatesofeffect.

13.DidthereviewauthorsaccountforRoBinindividualstudieswheninterpreting/discussingtheresultsofthereview?

ForYes:

includedonlylowriskofbiasRCTs

Yes

No

OR,ifRCTswithmoderateorhighRoB,orNRSIwereincludedthereviewprovidedadiscussionofthelikelyimpactofRoBontheresults

14.Didthereviewauthorsprovideasatisfactoryexplanationfor,anddiscussionof,anyheterogeneityobservedintheresultsofthereview?

ForYes:

Therewasnosignificantheterogeneityintheresults

Yes

No

ORifheterogeneitywaspresenttheauthorsperformedaninvestigationofsourcesofanyheterogeneityintheresultsanddiscussedtheimpactofthisontheresultsofthereview

15.Iftheyperformedquantitativesynthesisdidthereviewauthorscarryoutanadequateinvestigationofpublicationbias(smallstudybias)anddiscussitslikelyimpactontheresultsofthereview?

ForYes: