Quercetin-d3-hydrate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEQuercetin-d3hydrateCat.No.:HY-18085AS分⼦式:C₁₅H₉D₃O₈分⼦量:323.27作⽤靶点:PI3K;Autophagy;Mitophagy;Apoptosis;ReactiveOxygenSpecies作⽤通路:PI3K/Akt/mTOR;Autophagy;Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:30mg/mL(92.80mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.0934mL15.4669mL30.9339mL5mM0.6187mL3.0934mL6.1868mL10mM0.3093mL1.5467mL3.0934mLBIOLOGICALACTIVITY⽣物活性Quercetin-d3hydrate⼀种氘代的Quercetinhydrate(HY-18085A)，⼀种能刺激重组SIRT1的类酮，同时也⼀种PI3K抑制剂，其对PI3Kγ、PI3Kδ和PI3Kβ的IC50值分别为2.4μM、3.0μM和5.4μM[1]。IC50&TargetIC50:2.4±0.6μM(PI3Kγ),3.0±0.0μM(PI3Kδ),5.4±0.3μM(PI3Kβ)[1]体外研究Quercetinhydrateisatypeofplant-basedchemical,orphytochemical,usedasaningredientinsupplements,beveragesorfoods.Inseveralstudies,itmayhaveanti-inflammatoryandantioxidantproperties,anditisbeinginvestigatedforawiderangeofpotentialhealthbenefits.QuercetinhydrateisaPI3KinhibitorwithIC50of2.4-5.4μM.QuercetinhydratestronglyabrogatesPI3KandSrckinases,mildlyinhibitsAkt1/2,and1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEslightlyaffectedPKC,p38andERK1/2[1].QuercetinhydrateinhibitsTNF-inducedLDH%release,EC-dependentneutrophilsadhesiontobovinepulmonaryarteryendothelialcells(BPAEC),andBPAECDNAsynthesisandproliferation[2].体内研究CombinationofQuercetinhydrate(75mg/kg)and2-MethoxyestradiolenhancesinhibitionofhumanprostatecancerLNCaPandPC-3cellsxenografttumorgrowth[3].REFERENCES[1].LeyreNavarro-Núñez,etal.Effectofquercetinonplateletspreadingoncollagenandfibrinogenandonmultipleplateletkinases.Fitoterapia.2010Mar;81(2):75-80.[2].YuXB,etal.InhibitoryeffectsofproteinkinaseCinhibitorsontumornecrosisfactorinducedbovinepulmonaryarteryendothelialcellinjuries.YaoXueXueBao.1996;31(3):176-81.[3].YangF,etal.CombinationofQuercetinand2-MethoxyestradiolEnhancesInhibitionofHumanProstateCancerLNCaPandPC-3CellsXenograftTumorGrowth.PLoSOne.2015May26;10(5):e0128277.[4].TaoLiu,etal.QuercetinalleviateskidneyfibrosisbyreducingrenaltubularepithelialcellsenescencethroughtheSIRT1/PINK1/mitophagyaxis.LifeSci.2020Jul20;118116.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Fo