Darapladib-Standard-SB-480848-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDarapladib(Standard)Cat.No.:HY-10521RCASNo.:356057-34-6Synonyms:SB-480848(Standard)分⼦式:C₃₆H₃₈F₄N₄O₂S分⼦量:666.77作⽤靶点:Phospholipase;Apoptosis作⽤通路:MetabolicEnzyme/Protease;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Darapladib(Standard)Darapladib的分析标准品。本产品⽤于研究及分析应⽤。Darapladib(SB-480848)⼀种具有⼝服活性、选择性且可逆的Lp-PLA2抑制剂(IC50=0.25nM)。Darapladib可触发对神经胶质瘤细胞凋亡的不可逆作⽤并诱导周期停滞。Darapladib可⽤于动脉粥样硬化和癌症的研究。IC50&TargetIC50:0.25nM(Lp-PLA2)[1]REFERENCES[1].BlackieJA,etal.TheidentificationofclinicalcandidateSB-480848:apotentinhibitoroflipoprotein-associatedphospholipaseA2.BioorgMedChemLett.2003Mar24;13(6):1067-70.[2].HuMM,etal.Theinhibitionoflipoprotein-associatedphospholipaseA2exertsbeneficialeffectsagainstatherosclerosisinLDLR-deficientmice.ActaPharmacolSin.2011Oct;32(10):1253-1258.[3].WangYJ,etal.Theselectivelipoprotein-associatedphospholipaseA2inhibitordarapladibtriggersirreversibleactionsongliomacellapoptosisandmitochondrialdysfunction.ToxicolApplPharmacol.2020Sep1;402:115133.[4].RileyRF,etal.Darapladib,areversiblelipoprotein-associatedphospholipaseA2inhibitor,fortheoraltreatmentofatherosclerosisandcoronaryarterydisease.IDrugs.2009Oct;12(10):648-55.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a