Zacopride-hydrochloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEZacopridehydrochloride(Standard)Cat.No.:HY-103137RCASNo.:101303-98-4分⼦式:C₁₅H₂₁Cl₂N₃O₂分⼦量:346.25作⽤靶点:5-HTReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Zacopride(hydrochloride)(Standard)Zacopride(hydrochloride)的分析标准品。本产品⽤于研究及分析应⽤。Zacopridehydrochloride⼀种⾼效的5-HT3受体拮抗剂，5-HT3和5-HT4受体Kis值分别为0.38和373nM。Zacopridehydrochloride也⼀种中度的IK1通道激动剂。Zacopridehydrochloride具有显的抗⼼律失常和⼼脏保护作⽤[1][2][3]。REFERENCES[1].NeumannJ,etal.Zacopridestimulates5-HT4serotoninreceptorsinthehumanatrium.NaunynSchmiedebergsArchPharmacol.2024Sep;397(9):6821-6835.[2].PinkusLM,etal.UtilizationofZacoprideanditsR-andS-EnantiomersinStudiesof5-HT3Receptor“Subtypes”.Serotonin:MolecularBiology,ReceptorsandFunctionalEffects,1991:439-448.[3].NagakuraY,etal.Pharmacologicalpropertiesofanovelgastrointestinalprokineticbenzamideselectiveforhuman5-HT4receptorversushuman5-HT3receptor.PharmacolRes.1999May;39(5):375-82.[4].SancilioLF,etal.Emeticactivityofzacoprideinferretsanditsantagonismbypharmacologicalagents.EurJPharmacol.1990Jun8;181(3):303-6.[5].McNeishCS,etal.The5-HT3antagonistzacoprideattenuatescocaine-inducedincreasesinextracellulardopamineinratnucleusaccumbens.PharmacolBiochemBehav.1993Aug;45(4):759-63.[6].JäkäläP,etal.Theeffectsoftacrineandzacoprideontheperformanceofadultratsintheworkingmemorytask.GenPharmacol.1993May;24(3):675-9.[7].SancilioLF,etal.Studiesontheemeticandantiemeticpropertiesofzacoprideanditsenantiomers.EurJPharmacol.1991Jan17;192(3):365-9.[8].MeyerLC,etal.Zacoprideand8-OH-DPATreverseopioid-inducedrespiratorydepressionandhypoxiabutnotcatatonicimmobilizationingoats.AmJPhysiolRegulIntegrCompPhysiol.2006Feb;290(2):R405-13.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[9].DunnRW,etal.Preclinicalanxiolyticversusantipsychoticprofilesofthe5‐HT3antagonistsondansetron,zacopride,3α‐tropanyl‐1H‐indole‐3‐carboxylicacidester,and1αH,3α,5αH‐tropan‐3‐yl‐3,5‐dichlorobenzoate.Drugdevelopmentresearch,1991,23(4):289-300.[10].CostallB,etal.Zacopride:anxiolyticprofileinrodentandprimatemodelsofanxiety.JPharmPharmacol.1988Apr;40(4):302-5.[11].KiiY,etal.Effectsof5-HT4-receptoragonists,cisapride,mosapridecitrate,andzacopride,oncardiacactionpotentialsinguineapigisolatedpapillarymuscles.JCardiovascPharmacol.1997May;29(5):670-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalappli