年产3亿粒盐酸非索非那定胶囊生产车间设计

目录TOC\o"1-4"\h\z\u72721.工艺概述 191171.1盐酸非索非那定胶囊的概述 Designofproductionworkshopwithanannualoutputof300millionfexofenadinehydrochloridecapsulesAbstract:FexofenadinehydrochloridecapsulesareantihistamineswithselectiveperipheralH1receptorantagonism.Fexofenadinecannotcrosstheblood-brainbarrierandhasnocalmingeffectoranticholinergicagent.Clinically,antihistaminesarecommonlyusedinthetreatmentofallergicrhinitis.Fexofenadinehydrochloridecapsuleisanewgenerationofnon-sedativeantihistamines,whichhastheadvantagesofreceptorselectivity,cleartarget,rapidmetabolism,andfewadversereactions.ThemechanismofitstreatmentofallergicrhinitisisthatH1receptorandhistaminecompetewithhistaminetoeffecthistaminereceptorsonthecellmembraneandplayitsrolerapidlyandslowlyRelievethepatient'snasalitch,sprayandhypersecretionofnasalsecretion.Fexofenadinehydrochloridecapsuleisathirdgenerationantihistamine,whichismoreeffectiveandhasfewersideeffectsthanthesecondgenerationantihistaminescurrentlyusedinthemarket,terphenadine(Mindy),astimidazole(temistine),loratadine,andcetirizinehydrochloride,especiallywithlowcardiactoxicity.Itssafetyisgood,suitableforlarge-scaleproduction,combinedwiththeproductionprocessoffexofenadinehydrochloridecapsules,materialbalance,selecttheappropriateequipment,determinethecorrectflowofpeopleandlogistics,designtheoveralllayoutoftheworkshop,completetheproductionworkshopdesignoffexofenadinehydrochloridecapsules,maketheworkshopsafeandorderlyproduction,andprovideeffectivebasisforthemassproductionoffexofenadinehydrochloridecapsulesAccordingto.Keywords:Fexofenadinehydrochloride;Workshopdesign;Capsules.

附录附录I设备一览表序号设备名称规格型号生产能力台数产地1粉碎机FS180-4C10-120kg/h1广州雷迈机械设备有限公司2筛分机ZSY-35060-200kg/h1天津市云飞机械有限公司3混合制粒机HLSG-300P40-100kg/h1浙江明天机械有限公司4干燥器CT-C-O20-60kg/h1常州市常鑫药化机械厂5整粒机GZL-8050-100kg/h1青州市精诚医药装备制造有限公司6三维运动混合机SYH-400200kg1常州市久川干燥设备有限公司7填充机NJP1500A90000粒/h3北京嘉福瑞科有限公司8抛光机WK-9018万粒-42万粒1山东青州精诚机械有限公司9铝塑包装机DPB-250D3.5-23万粒2瑞安