MCI-225-hydrate-hydrochloride-DDP-225-hydrate-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEMCI-225hydratehydrochlorideCat.No.:HY-120810CASNo.:476148-82-0Synonyms:DDP-225hydratehydrochloride分子式:C₁₇H₂₀ClFN₄OS分子量:382.88作用靶点:5-HTReceptor作用通路:GPCR/GProtein;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性MCI-225(DDP-225)hydratehydrochloride是一种选择性口服活性去甲肾上腺素(NA)再摄取抑制剂，具有5-HT3受体拮抗作用。MCI-225hydratehydrochloride具有抗抑郁样和抗焦虑样特性。MCI-225hydratehydrochloride可用于焦虑症的研究。IC50&Target5-HT3Receptor体内研究Insocialinteraction(SI)testinrats,MCI-225(10and30mg/kg,po)hydratehydrochloridesignificantlyincreasesSItoanunfamiliarpartnerunderhighlightconditionswithoutchangesinambulation.MCI-225(10mg/kg,po)hydratehydrochlorideshowscomparableanxiolytic-likeeffectbetweensingleand5-dayrepeatedadministration[1].IntheMorris-typewatermazetaskinrats,MCI-225(1-10mg/kg,PO)hydratehydrochloridereducesthespatiallearningimpairmentinducedbyScopolamine(HY-N0296)(0.5mg/kg,IP)[2].Inapassiveavoidance(PA)taskinrats,administrationofMCI-225hydratehydrochloridepriortotraining(1-30mg/kg,PO)hydratehydrochloridelessenesthecarbondioxide(CO2)-inducedamnesiainadose-dependentmanner[2].MCI-225(1-100mg/kg)hydratehydrochloridedoesnotaffectgrossbehaviorinrats[2].REFERENCESEguchiJ,etal.Theanxiolytic-likeeffectofMCI-225,aselectiveNAreuptakeinhibitorwith5-HT3receptorantagonism.PharmacolBiochemBehav.2001Apr;68(4):677-83.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEEguchiJ,etal.EffectsofanovelcompoundMCI-225onimpairedlearningandmemoryinrats.PharmacolBiochemBehav.1994Jun;48(2):345-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379