3-Hydroxyhippuric-acid-d4-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE3-Hydroxyhippuricacid-d4Cat.No.:HY-178381S分⼦式:C₉H₅D₄NO₄分⼦量:199.2作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite作⽤通路:Others;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性3-Hydroxyhippuricacid-d4氘代标记的3-Hydroxyhippuricacid(HY-113085)。3-Hydroxyhippuricacid是⼀种酰⽢氨酸。3-Hydroxyhippuricacid可抑制⽝尿氨酸酶(kynureninase)(Ki=60μM)。3-Hydroxyhippuricacid在⾃闭症实验组体内浓度⾼于对照组。3-Hydroxyhippuricacid梭的标志物，与梭的含量呈正相关。3-Hydroxyhippuricacid⼉茶素饮⾷和葡萄多酚饮⾷的主代谢物之⼀[1][2][3]。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].Xiong,X.,etal.,(2016).Urinary3-(3-Hydroxyphenyl)-3-hydroxypropionicAcid,3-HydroxyphenylaceticAcid,and3-HydroxyhippuricAcidAreElevatedinChildrenwithAutismSpectrumDisorders.BioMedresearchinternational,2016,9485412.[2].Gonthier,M.P.,etal.,(2003).Microbialaromaticacidmetabolitesformedinthegutaccountforamajorfractionofthepolyphenolsexcretedinurineofratsfedredwinepolyphenols.TheJournalofnutrition,133(2),461–467.[3].Lima,S.,Kumar,S.,(2009).CrystalstructureoftheHomosapienskynureninase-3-hydroxyhippuricacidinhibitorcomplex:insightsintothemolecularbasisofkynureninasesubstratespecificity.Journalofmedicinalchemistry,52(2),389–396.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02