Atomoxetine-d7-hydrochloride-Tomoxetine-d-sub-7-sub-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAtomoxetine-d7hydrochlorideCat.No.:HY-17385S1Synonyms:Tomoxetine-d7hydrochloride;(R)-Tomoxetine-d7hydrochloride分⼦式:C₁₈H₁₇D₇ClNO分⼦量:312.89作⽤靶点:Isotope-LabeledCompounds;SerotoninTransporter;AdrenergicReceptor;SodiumChannel作⽤通路:Others;NeuronalSignaling;GPCR/GProtein;MembraneTransporter/IonChannel储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Atomoxetine-d7hydrochloride(Tomoxetine-d7hydrochloride)氘代标记的Atomoxetinehydrochloride(HY-17385)。Atomoxetinehydrochloride⼀种选择性去甲肾上腺素再摄取抑制剂(noradrenalinereuptake)，去甲肾上腺素(NE)、5-羟⾊胺(5-HT)和多巴胺(DA)转运体的Ki值分别为5nM、77nM和1451nM。Atomoxetinehydrochloride⼀种有效的Na+通道阻断剂(VGSCs)。Atomoxetinehydrochloride可⽤于注意⼒缺陷多动障碍(ADHD)的研究。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].BymasterFP,et,al.Atomoxetineincreasesextracellularlevelsofnorepinephrineanddopamineinprefrontalcortexofrat:apotentialmechanismforefficacyinattentiondeficit/hyperactivitydisorder.Neuropsychopharmacology.2002Nov;27(5):699-711.[2].TurnerM,et,al.Effectsofatomoxetineonlocomotoractivityandimpulsivityinthespontaneouslyhypertensiverat.BehavBrainRes.2013Apr15;243:28-37.[3].FöhrKJ,et,al.BlockofVoltage-GatedSodiumChannelsbyAtomoxetineinaState-andUse-dependentManner.FrontPharmacol.2021Feb25;12:622489.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;