Cathepsin-K-IN-9-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECathepsinK-IN-9Cat.No.:HY-179697CASNo.:2361420-28-0分⼦式:C₃₅H₄₁N₇O分⼦量:575.75作⽤靶点:Cathepsin作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性CathepsinK-IN-9⼀种选择性、强效且具有⼝服活性的CathepsinK抑制剂，其IC50为6.2nM。CathepsinK-IN-9对组织蛋⽩酶B、L和S的IC50均⼤于10000nM，表现出超过1600倍的选择性。CathepsinK-IN-9具有优异的安全性和代谢稳定性，可⽤于⾻质疏松症的研究。IC50&TargetcathepsinK6.2nM(IC50)体外研究CathepsinK-IN-9(Compound9d)(0.001–10μM;72h)demonstrateslowcytotoxicityinHEK293Tcells[1].CathepsinK-IN-9(10μM,120min)exhibitsweakinhibitionagainstfivemajorhumanCYPisozymes(1A2,2C9,2C19,2D6,3A4),withnosignificantriskofmetabolicinteractions[1].CathepsinK-IN-9inhibitsthehERGchannelathighconcentrations(IC50=447nM),butshowsnosignificantcardiotoxicityriskattherapeuticconcentrations[1].CathepsinK-IN-9exhibitsmoderatemetabolicstabilityinhuman,dog,rat,andmouselivermicrosomes,with77.1%,84.3%,57.6%,and69.1%ofthecompoundremainingafter30minutes,respectively[1].CellCytotoxicityAssay[1]CellLine:HEK293TcellsConcentration:0.001,0.004,0.01,0.01,0.1,0.3,1.1,3.3and10μMIncubationTime:72hResult:Maintainedcellvitalityatover70%.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEREFERENCES[1].LeeJ,etal.Pyrrolopyrimidines:ApromisingscaffoldforthedevelopmentofnovelcathepsinKinhibitors.EurJMedChem.2026;302(Pt2):118323.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589